Prefrontal cortical ChAT-VIP interneurons provide local excitation by cholinergic synaptic transmission and control attention

被引：70

作者：

Obermayer, Joshua ^{[1
]}

Luchicchi, Antonio ^{[1
,3
]}

Heistek, Tim S. ^{[1
]}

de Kloet, Sybren F. ^{[1
]}

Terra, Huub ^{[1
]}

Bruinsma, Bastiaan ^{[1
]}

Mnie-Filali, Ouissame ^{[1
]}

Kortleven, Christian ^{[1
]}

Galakhova, Anna A. ^{[1
]}

Khalil, Ayoub J. ^{[1
]}

Kroon, Tim ^{[1
,4
]}

Jonker, Allert J. ^{[2
]}

de Haan, Roel ^{[1
]}

van den Berg, Wilma D. J. ^{[2
]}

Goriounova, Natalia A. ^{[1
]}

de Kock, Christiaan P. J. ^{[1
]}

Pattij, Tommy ^{[2
]}

Mansvelder, Huibert D. ^{[1
]}

机构：

[1] Vrije Univ, Dept Integrat Neurophysiol, Amsterdam Neurosci, CNCR, Amsterdam, Netherlands

[2] Vrije Univ, Dept Anat & Neurosci, Amsterdam UMC, Amsterdam Neurosci, Amsterdam, Netherlands

[3] Vrije Univ, Dept Anat & Neurosci, Amsterdam UMC, Amsterdam Neurosci,Clin Neurosci, Amsterdam, Netherlands

[4] Kings Coll London, MRC Ctr Dev Neurobiol, London, England

来源：

NATURE COMMUNICATIONS | 2019年 / 10卷 / 1期

基金：

欧盟地平线“2020”;

关键词：

REACTION-TIME-TASK; ACETYLCHOLINE-RELEASE; DISYNAPTIC INHIBITION; SUSTAINED ATTENTION; BARREL CORTEX; NEURONS; PERFORMANCE; MECHANISMS; RAT; ACETYLTRANSFERASE;

D O I：

10.1038/s41467-019-13244-9

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Neocortical choline acetyltransferase (ChAT)-expressing interneurons are a subclass of vasoactive intestinal peptide (ChAT-VIP) neurons of which circuit and behavioural function are unknown. Here, we show that ChAT-VIP neurons directly excite neighbouring neurons in several layers through fast synaptic transmission of acetylcholine (ACh) in rodent medial prefrontal cortex (mPFC). Both interneurons in layers (L)1-3 as well as pyramidal neurons in L2/3 and L6 receive direct inputs from ChAT-VIP neurons mediated by fast cholinergic transmission. A fraction (10-20%) of postsynaptic neurons that received cholinergic input from ChAT-VIP interneurons also received GABAergic input from these neurons. In contrast to regular VIP interneurons, ChAT-VIP neurons did not disinhibit pyramidal neurons. Finally, we show that activity of these neurons is relevant for behaviour and they control attention behaviour distinctly from basal forebrain ACh inputs. Thus, ChAT-VIP neurons are a local source of cortical ACh that directly excite neurons throughout cortical layers and contribute to attention.

引用

页数：14

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