CSF D-serine concentrations are similar in Alzheimer's disease, other dementias, and elderly controls

被引：40

作者：

Biemans, Elisanne A. L. M. ^{[1
,2
]}

Verhoeven-Duif, Nanda M. ^{[3
]}

Gerrits, Johan ^{[3
]}

Claassen, Jurgen A. H. R. ^{[4
]}

Kuiperij, H. Bea ^{[1
,2
]}

Verbeek, Marcel M. ^{[1
,2
]}

机构：

[1] Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Dept Neurol, Med Ctr,Radboud Alzheimer Ctr, NL-6500 HB Nijmegen, Netherlands

[2] Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Dept Lab Med, Med Ctr,Radboud Alzheimer Ctr, NL-6500 HB Nijmegen, Netherlands

[3] Univ Med Ctr Utrecht, Ctr Mol Med, Utrecht, Netherlands

[4] Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Dept Geriatr Med, Med Ctr,Radboud Alzheimer Ctr, NL-6500 HB Nijmegen, Netherlands

来源：

NEUROBIOLOGY OF AGING | 2016年 / 42卷

关键词：

Alzheimer's disease; Dementia with Lewy bodies; Frontotemporal dementia; Biological markers; Cerebrospinal fluid; D-serine; CEREBROSPINAL-FLUID;

D O I：

10.1016/j.neurobiolaging.2016.03.017

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

030301 [社会学]; 100201 [内科学];

摘要：

Cerebrospinal fluid (CSF) levels of D-serine were recently reported as a potential new biomarker for Alzheimer's disease (AD), showing a perfect distinction between AD patients and healthy controls. In this study, we aimed to confirm these results and extend these previous findings to dementia with Lewy bodies and frontotemporal dementia. D-Serine levels in CSF of 29 AD patients, 8 dementia with Lewy bodies patients, 14 frontotemporal dementia patients, and 28 nondemented controls were measured using ultra-high-performance liquid chromatography-tandem mass spectrometry. In contrast to previous findings, in our study CSF D-serine levels were only slightly increased in AD patients compared with controls. CSF D-serine in AD did not differ from other dementias and was also not correlated to minimental state examination-scores. Owing to the large overlap of D-serine levels, we conclude that CSF D-serine is neither a suitable biomarker for AD nor for cognitive decline. (C) 2016 Elsevier Inc. All rights reserved.

引用

页码：213 / 216

页数：4

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