Synthesis and membrane permeability of PNA-peptide conjugates

被引：92

作者：

Simmons, CG

Pitts, AE

Mayfield, LD

Shay, JW

Corey, DR

机构：

[1] Univ Texas, SW Med Ctr, Howard Hughes Med Inst, Dept Pharmacol, Dallas, TX 75235 USA

[2] Univ Texas, SW Med Ctr, Dept Cell Biol & Neurosci, Dallas, TX 75235 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 23期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0960-894X(97)10136-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Chimeric molecules consisting of peptide nucleic acid oligomers (PNAs) and peptides derived from the third helix of the homeodomain of Antennapedia are taken up by mammalian cells in culture. Uptake is independent of orientation and occurs with high efficiency, suggesting that peptide conjugates are a promising strategy for intracellular PNA delivery. (C) 1997 Elsevier Science Ltd.

引用

收藏

页码：3001 / 3006

页数：6

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