In situ detection of Epstein-Barr virus in breast cancer

被引：59

作者：

Chu, JS

Chen, CC

Chang, KJ

机构：

[1] Natl Taiwan Univ, Coll Med, Dept Pathol, Taipei, Taiwan

[2] Natl Taiwan Univ, Coll Med, Dept Surg, Taipei 10018, Taiwan

来源：

CANCER LETTERS | 1998年 / 124卷 / 01期

关键词：

breast cancer; Epstein-Barr virus; immunohistochemistry; in situ hybridization;

D O I：

10.1016/S0304-3835(97)00449-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Epstein-Barr virus (EBV) is strongly associated with nasopharyngeal carcinoma and some lymphoepithelioma-like carcinomas from other anatomic sites. This study investigates the presence of (E) over dot BV in breast cancer. Immunohistochemistry for EBV proteins (EBV nuclear antigen-2 and latent membrane protein-1) and in situ hybridization for EBV-encoded small nuclear RNAs (EBER-1 and -2) were performed in 60 invasive breast cancers. None of the 60 breast cancer samples showed detectable EBV. These results suggest that EBV may not play a significant role in the etioloy of breast cancers in Taiwan. Published by Elsevier Science Ireland Ltd.

引用

页码：53 / 57

页数：5

共 27 条

[1] EPSTEIN-BARR VIRAL-DNA IN HODGKINS-DISEASE - AMPLIFICATION AND DETECTION USING THE POLYMERASE CHAIN-REACTION [J].