Protein tyrosine phosphatase PTPN22 in human autoimmunity

被引：128

作者：

Vang, Torkel

Miletic, Ana V.

Bottini, Nunzio

Mustelin, Tomas

机构：

[1] Burnham Inst Med Res, La Jolla, CA 92037 USA

[2] Univ So Calif, Inst Med Genet, Keck Sch Med, Los Angeles, CA 90033 USA

[3] Amgen Inc, Seattle, WA 98119 USA

来源：

AUTOIMMUNITY | 2007年 / 40卷 / 06期

关键词：

protein tyrosine phosphatase; human autoimmunity; Graves' disease; rheumatoid arthritis; type; 1; diabetes;

D O I：

10.1080/08916930701464897

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The discovery that a single-nucleotide polymorphism ( SNP) in lymphoid tyrosine phosphatase (LYP), encoded by the PTPN22 gene, is associated with type 1 diabetes (T1D) has now been verified by numerous studies and has been expanded to rheumatoid arthritis, juvenile rheumatoid arthritis (JRA), systemic lupus erythematosus, Graves' disease, generalized vitiligo and other human autoimmune diseases. In this paper, we discuss the association of PTPN22 with autoimmunity, the biochemistry of the PTPN22-encoded phosphatase, and the molecular mechanism(s) by which the disease-predisposing allele contributes to the development of human disease.

引用

页码：453 / 461

页数：9

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