New Updates Pertaining to Drug Delivery of Local Anesthetics in Particular Bupivacaine Using Lipid Nanoparticles

被引：57

作者：

Beiranvand, Siavash ^{[1
]}

Eatemadi, Ali ^{[2
]}

Karimi, Arash ^{[1
]}

机构：

[1] Lorestan Univ Med Sci, Dept Anesthesiol, Khorramabad, Iran

[2] Univ Tehran Med Sci, Sch Adv Technol Med, Dept Med Biotechnol, Tehran, Iran

来源：

NANOSCALE RESEARCH LETTERS | 2016年 / 11卷

关键词：

Local anesthetics; Drug delivery; Lipid nanoparticles; Bupivacaine; Toxicity; DOUBLE-BLIND; DEPOFOAM BUPIVACAINE; IN-VITRO; POSTSURGICAL ANALGESIA; LIPOSOMAL BUPIVACAINE; PAIN; ROPIVACAINE; LIDOCAINE; HEMORRHOIDECTOMY; DURATION;

D O I：

10.1186/s11671-016-1520-8

中图分类号：

TB3 [工程材料学];

学科分类号：

082905 [生物质能源与材料];

摘要：

Lipid nanoparticles (liposomes) were first described in 1965, and several work have led to development of important technical advances like triggered release liposomes and drug-loaded liposomes. These advances have led to numerous clinical trials in such diverse areas such as the delivery of anti-cancer, antifungal, and antibiotic drugs; the delivery of gene medicines; and most importantly the delivery of anesthesia drugs. Quite a number of liposomes are on the market, and many more are still in developmental stage. Lipid nanoparticles are the first nano-medicine delivery system to be advanced from laboratory concept to clinical application with high considerable clinical acceptance. Drug delivery systems for local anesthetics (LAs) have caught the interest of many researchers because there are many biomedical advantages connected to their application. There have been several formulation techniques to systemically deliver LA that include encapsulation in liposomes and complexation in cyclodextrins, nanoparticles, and to a little extent gold nanoparticles. The proposed formulations help to decrease the LA concentration utilized, increase its permeability, and most importantly increase the localization of the LA for a long period of time thereby leading to increase in the duration of the LA effect and finally to reduce any local and systemic toxicity. In this review, we will highlight on new updates pertaining to drug delivery of local anesthetics in particular bupivacaine using lipid nanoparticles.

引用

页数：10

共 56 条

[1]

Measurement of inclusive jet and dijet cross sections in proton-proton collisions at 7 TeV centre-of-mass energy with the ATLAS detector [J].

Aad, G. ;

Abbott, B. ;

Abdallah, J. ;

Abdelalim, A. A. ;

Abdesselam, A. ;

Abdinov, O. ;

Abi, B. ;

Abolins, M. ;

Abramowicz, H. ;

Abreu, H. ;

Acerbia, E. ;

Acharya, B. S. ;

Ackers, M. ;

Adams, D. L. ;

Addy, T. N. ;

Adelman, J. ;

Aderholz, M. ;

Adomeit, S. ;

Adorisio, C. ;

Adragna, P. ;

Adye, T. ;

Aefsky, S. ;

Aguilar-Saavedra, J. A. ;

Aharrouche, M. ;

Ahlen, S. P. ;

Ahles, F. ;

Ahmad, A. ;

Ahmed, H. ;

Ahsan, M. ;

Aielli, G. ;

Akdogan, T. ;

Akesson, T. P. ;

Akimoto, G. ;

Akimov, A. V. ;

Aktas, A. ;

Alam, M. S. ;

Alam, M. A. ;

Albrand, S. ;

Aleksa, M. ;

Aleksandrov, I. N. ;

Aleppo, M. ;

Alessandriaa, F. ;

Alexaa, C. ;

Alexander, G. ;

Alexandre, G. ;

Alexopoulos, T. ;

Alhroob, M. ;

Aliev, M. ;

Alimonti, G. ;

Alison, J. .

EUROPEAN PHYSICAL JOURNAL C, 2011, 71 (02) :1-59

[2]

Fine-Needle Aspiration, Touch Imprint, and Crush Preparation Cytology for Diagnosing Thyroid Malignancies in Thyroid Nodules [J].

Ahmadinejad, Mojtaba ;

Aliepour, Asghar ;

Anbari, Khatereh ;

Kaviani, Mojhgan ;

Ganjizadeh, Hasan ;

Nadri, Sedigheh ;

Foroutani, Niloufar ;

Meysami, Masoumeh ;

Almasi, Vahid .

INDIAN JOURNAL OF SURGERY, 2015, 77 :S480-S483

[3]

[Anonymous], ANN RES REV BIOL

[4]

Liposomes in drug delivery: a patent review (2007-present) [J].

Arias, Jose L. .

EXPERT OPINION ON THERAPEUTIC PATENTS, 2013, 23 (11) :1399-1414

[5]

Beiranvand Siavash, 2014, Acta Med Iran, V52, P909

[6]

REVIEW OF PARTICLE PHYSICS Particle Data Group [J].

Beringer, J. ;

Arguin, J. -F. ;

Barnett, R. M. ;

Copic, K. ;

Dahl, O. ;

Groom, D. E. ;

Lin, C. -J. ;

Lys, J. ;

Murayama, H. ;

Wohl, C. G. ;

Yao, W. -M. ;

Zyla, P. A. ;

Amsler, C. ;

Antonelli, M. ;

Asner, D. M. ;

Baer, H. ;

Band, H. R. ;

Basaglia, T. ;

Bauer, C. W. ;

Beatty, J. J. ;

Belousov, V. I. ;

Bergren, E. ;

Bernardi, G. ;

Bertl, W. ;

Bethke, S. ;

Bichsel, H. ;

Biebel, O. ;

Blucher, E. ;

Blusk, S. ;

Brooijmans, G. ;

Buchmueller, O. ;

Cahn, R. N. ;

Carena, M. ;

Ceccucci, A. ;

Chakraborty, D. ;

Chen, M. -C. ;

Chivukula, R. S. ;

Cowan, G. ;

D'Ambrosio, G. ;

Damour, T. ;

de Florian, D. ;

de Gouvea, A. ;

DeGrand, T. ;

de Jong, P. ;

Dissertori, G. ;

Dobrescu, B. ;

Doser, M. ;

Drees, M. ;

Edwards, D. A. ;

Eidelman, S. .

PHYSICAL REVIEW D, 2012, 86 (01)

[7]

A randomized, double-blind, dose-ranging study comparing wound infiltration of DepoFoam bupivacaine, an extended-release liposomal bupivacaine, to bupivacaine HCl for postsurgical analgesia in total knee arthroplasty [J].

Bramlett, Kenneth ;

Onel, Erol ;

Viscusi, Eugene R. ;

Jones, Kevin .

KNEE, 2012, 19 (05) :530-536

[8]

Brunton LaurenceL., 2011, Goodman Gilman's the pharmacological basis of therapeutics, V12

[9]

Comparison of toxicity effects of ropivacaine, bupivacaine, and lidocaine on rabbit intervertebral disc cells in vitro [J].

Cai, Xian-Yi ;

Xiong, Li-Ming ;

Yang, Shu-Hua ;

Shao, Zeng-Wu ;

Xie, Mao ;

Gao, Fei ;

Ding, Fan .

SPINE JOURNAL, 2014, 14 (03) :483-490

[10]

Novel biodegradable sandwich-structured nanofibrous drug-eluting membranes for repair of infected wounds: an in vitro and in vivo study [J].

Chen, Dave Wei-Chih ;

Liao, Jun-Yi ;

Liu, Shih-Jung ;

Chan, Err-Cheng .

INTERNATIONAL JOURNAL OF NANOMEDICINE, 2012, 7 :763-771

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