Effect of stress on the production of O2- in alveolar macrophages

被引：27

作者：

De Castro, CMMB

de Castro, RM

de Medeiros, AF

Santos, AQ

Silva, WTFE

de Lima, JL

机构：

[1] UFPE, Setor Microbiol Clin, Lab Imunopatol Keizo Asami, BR-50670901 Recife, PE, Brazil

[2] UFPE, Dept Nutr, Lab Fisiol, BR-50670901 Recife, PE, Brazil

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2000年 / 108卷 / 1-2期

关键词：

stress; superoxide; alveolar macrophages; glucocorticoid;

D O I：

10.1016/S0165-5728(00)00276-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Alveolar macrophages (AM) of male rats (100-250 g), stressed or not, were evaluated with relationship to superoxide production (SP). Plasma levels of corticosterone were measured. The control group showed larger SP than the stressed group in all intervals of time. Exposure in vitro of AM to a synthetic glucocorticoid for 40 min (the same time of restraint stress) inhibits SP. Therefore, it seems under stress situations there is an increase of plasma levels of corticosterone and a decrease of SP in AM after stimulation with PMA. O-2(-) is a potent microbicide and its reduction could cause the loss of microbicidal activity of AM. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：68 / 72

页数：5

共 24 条

[1] Effects of chronic mild stress (CMS) and imipramine administration, on spleen mononuclear cell proliferative response, serum corticosterone level and brain norepinephrine content in male mice [J].

Azpiroz, A ;

Fano, E ;

Garmendia, L ;

Arregi, A ;

Cacho, R ;

Beitia, G ;

Brain, PF .

PSYCHONEUROENDOCRINOLOGY, 1999, 24 (03) :345-361

[2] Superoxide: A two-edged sword [J].

Babior, BM .

BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, 1997, 30 (02) :141-155

[3] Influence of beta-endorphin on the production of reactive oxygen and nitrogen intermediates by rabbit alveolar macrophages [J].

Billert, H ;

Fiszer, D ;

Drobnik, L ;

Kurpisz, M .

GENERAL PHARMACOLOGY, 1998, 31 (03) :393-397

[4]

BLALOCK JE, 1985, J IMMUNOL, V135, P858

[5]

BRUCE SM, 1994, JAMA-J AM MED ASSOC, V19, P35

[6] MACROPHAGE ACTIVATION REVISITED [J].

CELADA, A ;

NATHAN, C .

IMMUNOLOGY TODAY, 1994, 15 (03) :100-102

[7]

CHANOCK SJ, 1994, J BIOL CHEM, V269, P24519

[8]

DANTZER R, 1991, NEUROPSY, V6, P511

[9] Interdependence of the endocrine and immune systems [J].

Dardenne, M ;

Savino, W .

ADVANCES IN NEUROIMMUNOLOGY, 1996, 6 (04) :297-307

[10]

De Simoni MG, 1998, BIOL SIGNAL RECEPT, V7, P33

← 1 2 3 →