Significance of Fas protein in squamous cell carcinoma of the larynx

被引:5
作者
Bayazit, Y [1 ]
Mumbuç, S
Uçak, R
Kanlikama, M
Bakir, K
机构
[1] Gaziantep Univ, Fac Med, Dept Ear Nose & Throat, Gaziantep, Turkey
[2] Gaziantep Univ, Fac Med, Dept Pathol, Gaziantep, Turkey
关键词
Fas; laryngeal carcinoma;
D O I
10.1080/000164800750046108
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
The purpose was to elucidate the clinical significance of Fas protein in laryngeal squamous cell carcinoma (LSSC). Medical records of 30 patients who were operated For LSCC between 1991 and 1997 were reviewed. and histopathological and immunohistochemical studies of the archival tumor tissues were performed. Conventional histopathology included tumor grading, mitotic counting (MC) and status of the cervical lymph nodes. The monoclonal antibodies to Fas (DAKO M 3554) and nm23 (DAKO A0096 Lot 035) proteins were used for immunohistochemical staining. Streptavidin-Biotin, horseradish method was used, Positive staining For both Fas and nm23 was obtained in 27 (90%) turner samples. There was no correlation between neck metastasis and Fas positivity (r = 0.126, p = 0.505 and chi(2) = 0.062, p = 0.996, respectively). Fas positivity did not correlate to grade (r = 0.282, p = 0.130), tumor size or T (r = 0.0457, p = 0.810, chi(2) = 0.0.018, p = 0.999) or laryngeal site of involvement (chi(2) = 0.0937, p = 0.992). However, a correlation was found between Fas and MC (r = 0.482, p = 0.007). There was also a correlation between Fas and nm23 positivity (r = 0.614, p < 0.0001). Fas protein expression has no prognostic value in LSCC, because the Fas values do not correlate with grade, stage or nodal status of neck. However, 90% of LSCCs expressed Fas protein. Understanding the Functional status of the Fas receptor proteins may lead to development of new therapeutic options For LSSC in the future.
引用
收藏
页码:557 / 561
页数:5
相关论文
共 23 条
[1]   Safety and antitumor activity of recombinant soluble Apo2 ligand [J].
Ashkenazi, A ;
Pai, RC ;
Fong, S ;
Leung, S ;
Lawrence, DA ;
Masters, SA ;
Blackie, C ;
Chang, L ;
McMurtrey, AE ;
Hebert, A ;
DeForge, L ;
Koumenis, IL ;
Lewis, D ;
Harris, L ;
Bussiere, J ;
Koeppen, H ;
Shahrokh, Z ;
Schwall, RH .
JOURNAL OF CLINICAL INVESTIGATION, 1999, 104 (02) :155-162
[2]   PROTECTION FROM FAS-MEDIATED APOPTOSIS BY A SOLUBLE FORM OF THE FAS MOLECULE [J].
CHENG, JH ;
ZHOU, T ;
LIU, CD ;
SHAPIRO, JP ;
BRAUER, MJ ;
KIEFER, MC ;
BARR, PJ ;
MOUNTZ, JD .
SCIENCE, 1994, 263 (5154) :1759-1762
[3]   Significance of Fas and retinoblastoma protein expression during the progression of Barrett's metaplasia to adenocarcinoma [J].
Coppola, D ;
Schreiber, RH ;
Mora, L ;
Dalton, W ;
Karl, RC .
ANNALS OF SURGICAL ONCOLOGY, 1999, 6 (03) :298-304
[4]  
Hedlund TE, 1998, PROSTATE, V36, P92, DOI 10.1002/(SICI)1097-0045(19980701)36:2<92::AID-PROS4>3.0.CO
[5]  
2-G
[6]  
Hellquist HB, 1997, ACTA OTO-LARYNGOL, P25
[7]  
Ito Y, 1998, ONCOL REP, V5, P41
[8]  
Kataoka, 1996, Oncologist, V1, P399
[9]  
Koomägi R, 1999, INT J CANCER, V84, P239, DOI 10.1002/(SICI)1097-0215(19990621)84:3<239::AID-IJC7>3.3.CO
[10]  
2-J