Design and synthesis of triglyceride analogue biotinylated suicide inhibitors for directed molecular evolution of lipolytic enzymes

被引：11

作者：

Deussen, HJ ^{[1
]}

Danielsen, S ^{[1
]}

Breinholt, J ^{[1
]}

Borchert, TV ^{[1
]}

机构：

[1] Novo Nordisk AS, Prot Discovery, DK-2880 Bagsvaerd, Denmark

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 17期

关键词：

D O I：

10.1016/S0960-894X(00)00396-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The design, Synthesis, and inhibition properties of two new triglyceride analogue biotinylated suicide inhibitors (2) and (3) for directed molecular evolution of lipolytic enzymes by phage-display is described. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：2027 / 2031

页数：5

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