Characterizing the physical genome

被引：43

作者：

Pollack, JR

Iyer, VR

机构：

[1] Stanford Univ, Sch Med, Dept Pathol, Stanford, CA 94305 USA

[2] Univ Texas, Inst Mol & Cellular Biol, Austin, TX 78712 USA

[3] Univ Texas, Sect Mol Genet & Microbiol, Austin, TX 78712 USA

来源：

NATURE GENETICS | 2002年 / 32卷 / Suppl 4期

关键词：

D O I：

10.1038/ng1035

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The genome of an organism is a dynamic physical entity, comprising genomic DNA bound to many different proteins and organized into chromosomes. A thorough characterization of the physical genome is relevant to our understanding of processes such as the regulation of gene expression, DNA replication and repair, recombination, chromosome segregation, epigenetic inheritance and genomic instability. Methods based on microarrays are beginning to provide a detailed picture of this physical genome, and they complement the genome-wide studies of mRNA expression profiling that have previously been so successful.

引用

页码：515 / 521

页数：7

共 70 条

[1] Tumour class prediction and discovery by microarray-based DNA methylation analysis -: art. no. e21 [J].

Adorján, P ;

Distler, J ;

Lipscher, E ;

Model, F ;

Müller, J ;

Pelet, C ;

Braun, A ;

Florl, AR ;

Gütig, D ;

Grabs, G ;

Howe, A ;

Kursar, M ;

Lesche, R ;

Leu, E ;

Lewin, A ;

Maier, S ;

Müller, V ;

Otto, T ;

Scholz, C ;

Schulz, WA ;

Seifert, HH ;

Schwope, I ;

Ziebarth, H ;

Berlin, K ;

Piepenbrock, C ;

Olek, A .

NUCLEIC ACIDS RESEARCH, 2002, 30 (05) :e21

[2] Comparative genomics of BCG vaccines by whole-genome DNA microarray [J].

Behr, MA ;

Wilson, MA ;

Gill, WP ;

Salamon, H ;

Schoolnik, GK ;

Rane, S ;

Small, PM .

SCIENCE, 1999, 284 (5419) :1520-1523

[3] Exploiting transcription factor binding site clustering to identify cis-regulatory modules involved in pattern formation in the Drosophila genome [J].

Berman, BP ;

Nibu, Y ;

Pfeiffer, BD ;

Tomancak, P ;

Celniker, SE ;

Levine, M ;

Rubin, GM ;

Eisen, MB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (02) :757-762

[4] High resolution deletion analysis of constitutional DNA from neurofibromatosis type 2 (NF2) patients using microarray-CGH [J].

Bruder, CEG ;

Hirvelä, C ;

Tapia-Paez, I ;

Fransson, I ;

Segraves, R ;

Hamilton, G ;

Zhang, XX ;

Evans, DG ;

Wallace, AJ ;

Baser, ME ;

Zucman-Rossi, J ;

Hergersberg, M ;

Boltshauser, E ;

Papi, L ;

Rouleau, GA ;

Poptodorov, G ;

Jordanova, A ;

Rask-Andersen, H ;

Kluwe, L ;

Mautner, V ;

Sainio, M ;

Hung, G ;

Mathiesen, T ;

Möller, C ;

Pulst, SM ;

Harder, H ;

Heiberg, A ;

Honda, M ;

Miimura, M ;

Sahlén, S ;

Blennow, E ;

Albertson, DG ;

Pinkel, D ;

Dumanski, JP .

HUMAN MOLECULAR GENETICS, 2001, 10 (03) :271-282

[5] Genome-wide detection of chromosomal imbalances in tumors using BAC microarrays [J].

Cai, WW ;

Mao, JH ;

Chow, CW ;

Damani, S ;

Balmain, A ;

Bradley, A .

NATURE BIOTECHNOLOGY, 2002, 20 (04) :393-396

[6] Identification of amplified and expressed genes in breast cancer by comparative hybridization onto microarrays of randomly selected cDNA clones [J].

Clark, J ;

Edwards, S ;

John, M ;

Flohr, P ;

Gordon, T ;

Maillard, K ;

Giddings, I ;

Brown, C ;

Bagherzadeh, A ;

Campbell, C ;

Shipley, J ;

Wooster, R ;

Cooper, CS .

GENES CHROMOSOMES & CANCER, 2002, 34 (01) :104-114

[7] The genome-wide localization of Rsc9, a component of the RSC chromatin-remodeling complex, changes in response to stress [J].

Damelin, M ;

Simon, I ;

Moy, TI ;

Wilson, B ;

Komili, S ;

Tempst, P ;

Roth, FP ;

Young, RA ;

Cairns, BR ;

Silver, PA .

MOLECULAR CELL, 2002, 9 (03) :563-573

[8] Comprehensive human genome amplification using multiple displacement amplification [J].

Dean, FB ;

Hosono, S ;

Fang, LH ;

Wu, XH ;

Faruqi, AF ;

Bray-Ward, P ;

Sun, ZY ;

Zong, QL ;

Du, YF ;

Du, J ;

Driscoll, M ;

Song, WM ;

Kingsmore, SF ;

Egholm, M ;

Lasken, RS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (08) :5261-5266

[9]

Fritz B, 2002, CANCER RES, V62, P2993

[10] Global mapping of meiotic recombination hotspots and coldspots in the yeast Saccharomyces cerevisiae [J].

Gerton, JL ;

DeRisi, J ;

Shroff, R ;

Lichten, M ;

Brown, PO ;

Petes, TD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (21) :11383-11390

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