Colonic inflammation increases Na+ currents in bladder sensory neurons

被引：50

作者：

Malykhina, AP ^{[1
]}

Qin, C ^{[1
]}

Foreman, RD ^{[1
]}

Akbarali, HI ^{[1
]}

机构：

[1] Univ Oklahoma, Hlth Sci Ctr, Dept Physiol, Oklahoma City, OK 73104 USA

来源：

NEUROREPORT | 2004年 / 15卷 / 17期

关键词：

dorsal root ganglion neurons; dextran sulfate sodium induced colitis; sodium current; visceral cross-sensitization;

D O I：

10.1097/00001756-200412030-00008

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

The purpose of this study was to determine whether sensitization of pre-spinal afferents induced by colonic inflammation can affect the physiology of the urinary bladder. Tetrodotoxin-resistant (TTX-R) Na+ currents were examined in bladder sensory neurons after experimental colitis. Cell bodies of bladder dorsal root ganglia were retrogradely labeled and TTX-R Na+ currents were recorded in capsaicin-sensitive neurons. Colitis significantly enhanced response of bladder neurons EO capsaicin by similar to60% and the peak amplitude of TTX-R Na+ current by 51%. These results suggest that colonic inflammation leads to increased excitability of nociceptive bladder neurons.

引用

收藏

页码：2601 / 2605

页数：5

相关论文

共 25 条

[1]

Interstitial cystitis: Unexplained associations with other chronic disease and pain syndromes [J].

Alagiri, M ;

Chottiner, S ;

Ratner, V ;

Slade, D ;

Hanno, PM .

UROLOGY, 1997, 49 (5A) :52-57

[2]

Local inflammation increases vanilloid receptor 1 expression within distinct subgroups of DRG neurons [J].

Amaya, F ;

Oh-Hashi, K ;

Naruse, Y ;

Iijima, N ;

Ueda, M ;

Shimosato, G ;

Tominaga, M ;

Tanaka, Y ;

Tanaka, M .

BRAIN RESEARCH, 2003, 963 (1-2) :190-196

[3]

Two TTX-resistant Na+ currents in mouse colonic dorsal root ganglia neurons and their role in colitis-induced hyperexcitability [J].

Beyak, MJ ;

Ramji, N ;

Krol, KM ;

Kawaja, MD ;

Vanner, SJ .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2004, 287 (04) :G845-G855

[4]

Mild gastritis alters voltage-sensitive sodium currents in gastric sensory neurons in rats [J].

Bielefeldt, K ;

Ozaki, N ;

Gebhart, GF .

GASTROENTEROLOGY, 2002, 122 (03) :752-761

[5]

Changes in the expression of tetrodotoxin-sensitive sodium channels within dorsal root ganglia neurons in inflammatory pain [J].

Black, JA ;

Liu, SJ ;

Tanaka, M ;

Cummins, TR ;

Waxman, SG .

PAIN, 2004, 108 (03) :237-247

[6]

Impaired nociception and pain sensation in mice lacking the capsaicin receptor [J].

Caterina, MJ ;

Leffler, A ;

Malmberg, AB ;

Martin, WJ ;

Trafton, J ;

Petersen-Zeitz, KR ;

Koltzenburg, M ;

Basbaum, AI ;

Julius, D .

SCIENCE, 2000, 288 (5464) :306-313

[7]

Differential expression of tetrodotoxin-resistant sodium channels NaV1.8 and NaV1.9 in normal and inflamed rats [J].

Coggeshall, RE ;

Tate, S ;

Carlton, SM .

NEUROSCIENCE LETTERS, 2004, 355 (1-2) :45-48

[8]

CROSS-EXCITATION IN DORSAL-ROOT GANGLIA OF NERVE-INJURED AND INTACT RATS [J].

DEVOR, M ;

WALL, PD .

JOURNAL OF NEUROPHYSIOLOGY, 1990, 64 (06) :1733-1746

[9]

Changes in somatic action potential shape in guinea-pig nociceptive primary afferent neurones during inflammation in vivo [J].

Djouhri, L ;

Lawson, SN .

JOURNAL OF PHYSIOLOGY-LONDON, 1999, 520 (02) :565-576

[10]

The TTX-resistant sodium channel Nav1.8(SNS/PN3):: expression and correlation with membrane properties in rat nociceptive primary afferent neurons [J].

Djouhri, L ;

Fang, X ;

Okuse, K ;

Wood, JN ;

Berry, CM ;

Lawson, SN .

JOURNAL OF PHYSIOLOGY-LONDON, 2003, 550 (03) :739-752