Galectin-3 and Plasma Cytokines in Patients With Acute Myocardial Infarction

被引：18

作者：

Alturfan, A. Ata ^{[1
]}

Basar, Isik ^{[2
]}

Emekli-Alturfan, Ebru ^{[3
]}

Ayan, Faruk ^{[2
]}

Koldas, Lale ^{[2
]}

Emekli, Nesrin ^{[4
]}

机构：

[1] Istanbul Univ, Dept Biochem, Istanbul, Turkey

[2] Cerrahpasa Med Fac, Dept Cardiol, Istanbul, Turkey

[3] Marmara Univ, Fac Dent, Dept Biochem, Nisantasi, Istanbul, Turkey

[4] Medipol Univ, Fac Med, Dept Biochem, Istanbul, Turkey

来源：

LABMEDICINE | 2014年 / 45卷 / 04期

关键词：

Galectin-3; AMI; inflammation; cytokines; CRP; TNF-alpha; ACUTE CORONARY SYNDROME; TUMOR-NECROSIS-FACTOR; C-REACTIVE PROTEIN; ARTERY-DISEASE; HEART-FAILURE; INTERLEUKIN-6; INFLAMMATION; CELLS; RELEASE; MARKERS;

D O I：

10.1309/LM3JZKBDA7D4QFOC

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

100118 [医学信息学]; 100208 [临床检验诊断学];

摘要：

Objective: To investigate the concentrations of plasma cytokines and Galectin-3 (Gal-3) as inflammatory markers in patients with acute myocardial infarction (AMI). Methods: The study population consisted of 29 patients with AMI and 29 healthy control subjects. We measured Gal-3, tumor necrosis factor alpha (TNF-alpha), and interleukin-6 (IL-6) levels in plasma using enzyme-linked immunosorbent assays (ELISAs). We measured levels of C-reactive protein (CRP) via the nephelometric method. Results: Patients with AMI showed significantly higher plasma Gal-3, TNF-alpha, and IL-6 levels compared with controls. Gal-3 levels were positively and significantly correlated with plasma IL-6, TNF-alpha, and CRP levels in the control and patient groups. Conclusion: Our findings suggest that Gal-3 can be a new circulating biomarker of inflammation associated with AMI.

引用

页码：332 / 337

页数：6

共 37 条

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