Solid-phase synthesis of substituted glutamic acid derivatives via Michael addition reactions

被引：30

作者：

Domínguez, E

O'Donnell, MJ

Scott, WL

机构：

[1] Ctr Invest Lilly, Madrid 28130, Spain

[2] Indiana Univ Purdue Univ, Dept Chem, Indianapolis, IN 46202 USA

[3] Eli Lilly & Co, Lilly Res Labs, Res Technol & Prot, Indianapolis, IN 46285 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 15期

关键词：

D O I：

10.1016/S0040-4039(98)00165-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The conjugate addition of Michael accepters to the resin-bound benzophenone imine of glycine leads to a variety of racemic unnatural glutamic acid derivatives. This new approach expands the scope of unnatural amino acid and peptide synthesis (UPS). (C) 1998 Elsevier Science Ltd. All rights reserved.

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收藏

页码：2167 / 2170

页数：4

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