Docking domains and substrate-specificity determination for MAP kinases

被引：392

作者：

Sharrocks, AD

Yang, SH

Galanis, A

机构：

[1] Univ Manchester, Sch Biol Sci, Manchester M13 9PT, Lancs, England

[2] Newcastle Univ, Sch Med, Sch Biochem & Genet, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2000年 / 25卷 / 09期

基金：

英国惠康基金; 英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1016/S0968-0004(00)01627-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Signalling specificity in eukaryotic cells is maintained by several mechanisms. One mechanism by which mitogen-activated protein (MAP) kinases ensure their specificity of action is by interacting with their substrates through docking domains. These docking domains recruit the kinases to the correct substrates and enhance their fidelity and efficiency of action. Additional specificity determinants in the substrates serve to enhance the specificity of substrate phosphorylation by MAP kinases further.

引用

收藏

页码：448 / 453

页数：6

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