Laboratory criteria for menopause in women using oral contraceptives

被引:21
作者
Creinin, MD
机构
关键词
oral contraceptives; menopause; FSH; LH; E(2);
D O I
10.1016/S0015-0282(16)58394-0
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: To evaluate laboratory criteria for menopause in women taking oral contraceptives (OC). Design: Prospective, uncontrolled pilot study. Setting: San Francisco General Hospital, San Francisco, California, and Magee-Womens Hospital, Pittsburgh, Pennsylvania. Patients: Twenty-eight menopausal women. Interventions: Fourteen menopausal women received triphasic 35 mu g ethinyl E(2) and 180-215-250 mu g norgestimate, and 14 menopausal women received monophasic 30 mu g ethinyl E(2)-150 mu g desogestrel. Main Outcome Measures: Serum FSH, LH, and E(2) levels were evaluated on days 14 and 28 (day 7 of the pill-free interval) of the third cycle of pills. Results: Twelve women in each group completed the study. Fifteen (62.5%) subjects still had a serum FSH <30 mIU/mL (30 IU/L) on the 7th day of the pill-free interval of the third pill package. All subjects had a serum FSH:LH ratio >1 and 20 of 21 (95%) subjects had E(2) < 20 pg/mL (73 pmol/L) at the end of the pill-free interval of the third cycle. Conclusions: Measuring FSH on the 7th day of the pill-free interval is not a sensitive test for menopause. Serum FSH:LH ratio >1 or E(2) < 20 pg/mL (73 pmol/L) on the 7th day of the pill-free interval may be a more appropriate marker of menopause in women using OC in the later reproductive years.
引用
收藏
页码:101 / 104
页数:4
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