Novel A-ring cleaved analogs of oleanolic and ursolic acids which affect growth regulation in NRP.152 prostate cells

被引：39

作者：

Finlay, HJ

Honda, T

Gribble, GW

Danielpour, D

Benoit, NE

Suh, N

Williams, C

Sporn, MB

机构：

[1] DARTMOUTH COLL,DEPT CHEM,HANOVER,NH 03755

[2] NCI,BETHESDA,MD 20892

[3] DARTMOUTH COLL,HITCHCOCK MED CTR,DARTMOUTH MED SCH,DEPT PHARMACOL & TOXICOL,HANOVER,NH 03755

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 13期

关键词：

D O I：

10.1016/S0960-894X(97)00310-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Syntheses of eight novel A-ring cleaved oleanane and ursane analogs an described. These compounds were assessed for their ability to inhibit cell proliferation in NRP.152 prostate cells. Four A-ring cleaved derivatives showed significant activity; 5 beta-(1-methyl-2-ethyl)-10 alpha-(3-aminopropyl)-des-A-urs-12-en-28-oic acid was the most active compound, (IC50, 0.3 mu M). (C) 1997 Elsevier Science Ltd.

引用

页码：1769 / 1772

页数：4

共 18 条

[1] TRITERPENOIDS .4. SOME OBSERVATIONS ON THE CONSTITUTION OF LANOSTADIENOL (LANOSTEROL) [J].