Nuclear transport: Target for therapy

被引：53

作者：

Faustino, R. S.

Nelson, T. J.

Terzic, A.

Perez-Terzic, C. ^{[1
]}

机构：

[1] Mayo Clin, Marriott Heart Dis Res Program, Div Cardiovasc Dis, Dept Med, Rochester, MN 55905 USA

[2] Mayo Clin, Dept Mol Pharmacol, Rochester, MN USA

[3] Mayo Clin, Dept Expt Therapeut, Rochester, MN USA

[4] Mayo Clin, Dept Med Genet, Rochester, MN USA

[5] Mayo Clin, Dept Phys Med & Rehabil, Rochester, MN USA

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2007年 / 81卷 / 06期

关键词：

D O I：

10.1038/sj.clpt.6100141

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Drugs directed at plasma membrane receptors target environment-cell interactions and are the mainstay of clinical pharmacology. Decoding mechanisms that govern intracellular signaling has recently opened new therapeutic avenues for interventions at cytosol-organellar interfaces. The nuclear envelope and nuclear transport machinery have emerged central in the discovery and development of experimental therapeutics capable of modulating cellular genetic programs. Insight into nucleocytoplasmic exchange has unmasked promising anticancer, antiviral, and anti-inflammatory strategies.

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收藏

页码：880 / 886

页数：7

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