Renal endothelial function in humans

被引：8

作者：

Mimran, A ^{[1
]}

机构：

[1] Hosp Lapeyronie, Dept Internal Med, F-34295 Montpellier, France

来源：

CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION | 1998年 / 7卷 / 02期

关键词：

D O I：

10.1097/00041552-199803000-00002

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Animal experiments have shown extensively that the endothelial generation of nitric oxide participates in the regulation of renal haemodynamics and function, probably as a factor modulating the effects of endogenous vasoconstrictors. Although the endothelial function of the systemic vasculature is assessed through the vasodilatory effect of acetylcholine, only L-arginine infusion is available for studies of the influence of nitric oxide on the renal circulation in humans. In addition to peripheral vessels, L-arginine is a potent renal vasodilator, having no effect on the glomerular filtration rate; and the renal relaxation induced by L-arginine is markedly blunted in patients with essential hypertension. A few studies showing the renal vasoconstrictor effect of an inhibitor of nitric oxide synthesis have been reported. (C) 1998 Rapid Science Ltd.

引用

页码：149 / 152

页数：4

共 32 条

[1] TOPOGRAPHY OF NITRIC-OXIDE SYNTHESIS BY LOCALIZING CONSTITUTIVE NO SYNTHASES IN MAMMALIAN KIDNEY [J].

BACHMANN, S ;

BOSSE, HM ;

MUNDEL, P .

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL FLUID AND ELECTROLYTE PHYSIOLOGY, 1995, 268 (05) :F885-F898

[2] Effects of systemic NO synthesis inhibition on RPF, GFR, U-Na, and vasoactive hormones in healthy humans [J].

Bech, JN ;

Nielsen, CB ;

Pedersen, EB .

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL FLUID AND ELECTROLYTE PHYSIOLOGY, 1996, 270 (05) :F845-F851

[3]

BIJLSMA JA, 1995, J AM SOC NEPHROL, V5, P1508

[4] L-ARGININE INFUSION DECREASES PERIPHERAL ARTERIAL RESISTANCE AND INHIBITS PLATELET-AGGREGATION IN HEALTHY-SUBJECTS [J].

BODEBOGER, SM ;

BOGER, RH ;

CREUTZIG, A ;

TSIKAS, D ;

GUTZKI, FM ;

ALEXANDER, K ;

FROLICH, JC .

CLINICAL SCIENCE, 1994, 87 (03) :303-310

[5] DILATOR ACTIONS OF ARGININE IN HUMAN PERIPHERAL VASCULATURE [J].

CALVER, A ;

COLLIER, J ;

VALLANCE, P .

CLINICAL SCIENCE, 1991, 81 (05) :695-700

[6] EFFECT OF AMINO-ACID INFUSION ON RENAL HEMODYNAMICS IN HUMANS [J].

CASTELLINO, P ;

CODA, B ;

DEFRONZO, RA .

AMERICAN JOURNAL OF PHYSIOLOGY, 1986, 251 (01) :F132-F140

[7] EFFECT OF CAPTOPRIL AND ENALAPRIL ON ENDOTHELIAL FUNCTION IN HYPERTENSIVE PATIENTS [J].

CREAGER, MA ;

RODDY, MA .

HYPERTENSION, 1994, 24 (04) :499-505

[8] FOCAL AND SEGMENTAL GLOMERULOSCLEROSIS - ANALOGIES TO ATHEROSCLEROSIS [J].

DIAMOND, JR ;

KARNOVSKY, MJ .

KIDNEY INTERNATIONAL, 1988, 33 (05) :917-924

[9] Nifedipine attenuates systemic and renal vasoconstriction during nitric oxide inhibition in humans [J].

DijkhorstOei, LT ;

Rabelink, TJ ;

Boer, P ;

Koomans, HA .

HYPERTENSION, 1997, 29 (05) :1192-1198

[10] INHIBITION OF NITRIC-OXIDE SYNTHESIS IN FOREARM VASCULATURE OF INSULIN-DEPENDENT DIABETIC-PATIENTS - BLUNTED VASOCONSTRICTION IN PATIENTS WITH MICROALBUMINURIA [J].

ELLIOTT, TG ;

COCKCROFT, JR ;

GROOP, PH ;

VIBERTI, GC ;

RITTER, JM .

CLINICAL SCIENCE, 1993, 85 (06) :687-693

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