The Hox genes and their roles in oncogenesis

被引：690

作者：

Shah, Nilay ^{[1
]}

Sukumar, Saraswati ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA

来源：

NATURE REVIEWS CANCER | 2010年 / 10卷 / 05期

关键词：

2-GENE EXPRESSION RATIO; PROSTATE-CANCER CELLS; BREAST-CANCER; HOMEOBOX GENES; STEM-CELLS; HOMEODOMAIN PROTEIN; DIFFERENTIAL EXPRESSION; TRANSCRIPTION FACTORS; NEUROBLASTOMA-CELLS; MYELOID PROGENITORS;

D O I：

10.1038/nrc2826

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hox genes, a highly conserved subgroup of the homeobox superfamily, have crucial roles in development, regulating numerous processes including apoptosis, receptor signalling, differentiation, motility and angiogenesis. Aberrations in Hox gene expression have been reported in abnormal development and malignancy, indicating that altered expression of Hox genes could be important for both oncogenesis and tumour suppression, depending on context. Therefore, Hox gene expression could be important in diagnosis and therapy.

引用

页码：361 / 371

页数：12

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