A mild, highly selective and remarkably easy procedure for deprotection of aromatic acetates using ammonium acetate as a neutral catalyst in aqueous medium

被引：57

作者：

Ramesh, C ^{[1
]}

Mahender, G ^{[1
]}

Ravindranath, N ^{[1
]}

Das, B ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Div Organ Chem 1, Hyderabad 500007, Andhra Pradesh, India

来源：

TETRAHEDRON | 2003年 / 59卷 / 07期

关键词：

aromatic acetates; ammonium acetate; deprotection; bioactive phenolic compounds; venkatasin;

D O I：

10.1016/S0040-4020(02)01635-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Ammonium acetate was found to catalyze efficiently the selective deprotection of aromatic acetates in the presence of various sensitive functionalities in aqueous methanol under neutral conditions at room temperature to yield the corresponding phenols in excellent yields. The method has been utilized for deprotection of acetates of several naturally occurring bioactive phenolic compounds and for preparation of venkatasin, a natural coumarino-lignan, from the anticancer compound cleorniscosin A. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：1049 / 1054

页数：6

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