Cell-cell interaction mediated by cadherin-11 directly regulates the differentiation of mesenchymal cells into the cells of the osteo-lineage and the chondro-lineage

被引：84

作者：

Kii, I

Amizuka, N

Shimomura, J

Saga, Y

Kudo, A

机构：

[1] Tokyo Inst Technol, Dept Life Sci, Yokohama, Kanagawa 227, Japan

[2] Niigata Univ, Grad Sch Med & Dent Sci, Dept Oral Biol Sci, Div Oral Anat, Niigata, Japan

[3] Niigata Univ, Ctr Transdisciplinary Res, Niigata, Japan

[4] Natl Inst Genet, Mammalian Dev Lab, Mishima, Shizuoka 411, Japan

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2004年 / 19卷 / 11期

关键词：

cadherin-11; N-cadherin; bone; cartilage;

D O I：

10.1359/JBMR.040812

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We studied cadherin-11 function in the differentiation of mesenchymal cells. Teratomas harboring the cadherin-11 gene generated bone and cartilage preferentially. Cadherin-11 transfectants of C2C12 cells and cadherin-11 and/or N-cadherin transfectants of L cells showed that cadherin-11 together with N-cadherin-induced expression of ALP and FGF receptor 2. These results suggest that cadherin-11 directly regulates the differentiation of mesenchymal cells into the cells of the osteo-lineage and the chondro-lineage in a different manner from N-cadherin.

引用

收藏

页码：1840 / 1849

页数：10

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