Protein dynamics from NMR

被引：443

作者：

Ishima, R ^{[1
]}

Torchia, DA ^{[1
]}

机构：

[1] Natl Inst Dent & Craniofacial Res, Struct Mol Biol Unit, NIH, Bethesda, MD 20892 USA

来源：

NATURE STRUCTURAL BIOLOGY | 2000年 / 7卷 / 09期

关键词：

D O I：

10.1038/78963

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review surveys recent investigations of conformational fluctuations of proteins in solution using NMR techniques. Advances in experimental methods have provided more accurate means of characterizing fast and slow internal motions as well as overall diffusion. The information obtained from NMR dynamics experiments provides insights into specific structural changes or configurational energetics associated with function. A variety of applications illustrate that studies of protein dynamics provide insights into protein-protein interactions, target recognition, ligand binding, and enzyme function.

引用

页码：740 / 743

页数：4

共 67 条

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