Cytotoxicity of TRAIL/anticancer drug combinations in human normal cells

被引：34

作者：

Meurette, Olivier

Fontaine, Anne

Rebillard, Amelie

Le Moigne, Gwenaelle

Lamy, Thierry

Lagadic-Gossmann, Dominique

Dimanche-Boitrel, Marie-Therese

机构：

[1] Univ Rennes 1, INSERM, U620, Fac Pharm,IFR 140, F-35043 Rennes, France

[2] Hop Pontchaillou, Dept Hematol, Rennes, France

来源：

SIGNAL TRANSDUCTION PATHWAYS, PT A: APOPTOTIC AND EXTRACELLULAR SIGNALING | 2006年 / 1090卷

关键词：

TRAIL; human primary hepatocytes; lymphocytes; neutrophils;

D O I：

10.1196/annals.1378.023

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

TRAIL (TNF-alpha-Related Apoptosis-Inducing Ligand) is a promising anticancer agent. In fact, it induces apoptosis in cancer cells and not in most normal cells. Nevertheless, certain cancer cells are resistant to TRAIL-induced apoptosis and this could limit TRAIL's efficiency in cancer therapy. To overcome TRAIL resistance, a combination of TRAIL with chemotherapy could be used in cancer treatment. However, sensitivity of human normal cells to such combinations is not well known. We showed in this study that TRAIL/cisplatin, in contrast to TRAIL/5-fluorouracil, was toxic toward human primary hepatocytes and resting lymphocytes. Furthermore, both combinations are toxic toward PHA-IL2-activated lymphocytes. In contrast, freshly isolated neutrophils are resistant to TRAIL in combination or not with anticancer drugs.

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页码：209 / 216

页数：8

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