Eleven years of malaria surveillance in a Sudanese village highlights unexpected variation in individual disease susceptibility and outbreak severity

被引:36
作者
Creasey, A
Giha, H
Hamad, AA
El Hassan, IM
Theander, TG
Arnot, DE
机构
[1] Univ Edinburgh, Inst Cell Anim & Populat Biol, Edinburgh EH9 3JT, Midlothian, Scotland
[2] Minist Hlth Sudan, Natl Hlth Lab, Natl Malaria Adm, Khartoum, Sudan
[3] Univ Khartoum, Inst Endem Dis, Khartoum, Sudan
[4] Univ Khartoum, Dept Biochem, Khartoum, Sudan
[5] Univ Copenhagen, Ctr Med Parasitol, Copenhagen, Denmark
关键词
Plasmodium falciparum malaria; clinical incidence; longitudinal analysis; Sudan;
D O I
10.1017/S0031182004005724
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
An analysis is presented of continuous data collected over 11 years based on 1902 600 person/days of observation on the malaria experience of the people of Daraweesh, a village in eastern Sudan. Malaria transmission is hypo-endemic: the acquisition of clinical immunity with age is not as obvious as in more holo-endemic areas and malaria remained a problem in all age groups throughout the study. However, this population, who are of Fulani origin, showed a distinctly variable level of disease susceptibility. Thirty-two percent of the village never reported malaria symptoms or required malaria treatment while others experienced Lip to 8 clinical episodes over the 11 years of observation. Malaria incidence was clearly influenced by drought but much less obviously by rainfall. To what extent outbreak patterns are explicable in terms of anopheline factors, and to human immune factors, remains an interesting question for malaria modelling in this, and in other low transmission zones, such as the burgeoning urban areas of modern Africa.
引用
收藏
页码:263 / 271
页数:9
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