Effects of 2-(substituted-sulfanyl)-3,5-dihydro-imidazole-4-one and 2-(substituted-sulfanyl)-1H-imidazole-4,5-dione derivatives on serum HDL-cholesterol

被引：5

作者：

Elokdah, H

Sulkowski, T

Cochran, D

McKean, ML

Quinet, E

机构：

[1] Wyeth Ayerst Res, Chem Sci, Med Chem, Princeton, NJ 08543 USA

[2] Wyeth Ayerst Res, Chem Sci, Discovery Analyt Chem, Princeton, NJ 08543 USA

[3] Wyeth Ayerst Res, Cardiovasc Womens Hlth, Philadelphia, PA 19101 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 16期

关键词：

D O I：

10.1016/S0960-894X(00)00338-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 2-substituted sulfanyl-3,5-dihydro-imidazole-4-one and 2-substituted sulfanyl-1H-imidazole-4,5-diones was prepared and shown to increase high density lipoprotein cholesterol over other lipid fractions. Compound If showed efficacy in additional animal models. The major metabolite of If was isolated and its synthesis is reported. The effects of the metabolite on the lipid profile in rats were investigated. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1791 / 1794

页数：4

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