Enzymatic synthesis of the acrylic esters: a comparative study

被引：18

作者：

Athawale, V ^{[1
]}

Manjrekar, N ^{[1
]}

机构：

[1] Univ Bombay, Dept Chem, Bombay 400098, Maharashtra, India

来源：

JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC | 2000年 / 10卷 / 06期

关键词：

acylation; enzymatic synthesis; lipase; oxime acrylate; transesterification;

D O I：

10.1016/S1381-1177(00)00008-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Various acrylic esters were synthesized by Candida cylindracea lipase (CCL) catalysed transesterification with different alcohols. A comparative study was carried out using 2,3-butanedione mono-oxime acrylate and vinyl acrylate as acylating agents. The rate of conversion was faster when oxime acrylate was used as acylating agent as compared to vinyl acrylate. Effect of solvents on the rate of conversion was studied and diisopropyl ether (DIPE) was proved to be a better solvent as compared to CHCl3 and THF. The effect of various structural aspects of the substrates on the rate of conversion was studied. Among the linear alcohols studied, ease of conversion was found to be in the order of n-octanol > n-hexanol > n-butanol. Up to 80% conversion was achieved in the case of cyclohexyl methanol. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：551 / 554

页数：4

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