Genomic discovery reveals a molecular system for resistance to oxidative and endoplasmic reticulum stress in cultured glioma

被引：10

作者：

Fathallah-Shaykh, HM ^{[1
]}

机构：

[1] Rush Univ, Ctr Med, Sect Neurooncol, Dept Neurol Sci, Chicago, IL 60612 USA

来源：

ARCHIVES OF NEUROLOGY | 2005年 / 62卷 / 02期

关键词：

D O I：

10.1001/archneur.62.2.233

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Oxygen is required for respiration and the energetic processes that enable aerobic life. Reactive oxygen species and free radicals, by-products of oxygen use, cause DNA damage and induce endoplasmic reticulum (ER) stress and apoptosis. However, rapidly multiplying cancer cells are resistant to ER and oxidative stress-induced apoptosis. The present article reports the results of highly specific genome-scale expression discovery used to identify genes differentially expressed in cultured glioma cells vs normal brain tissue. The discovered states of expression reveal a cohesive molecular system that protects rapidly growing glioma cells from ER and oxidative stress-induced apoptosis.

引用

页码：233 / 236

页数：4

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