The small airways and distal lung compartment in asthma and COPD: a time for reappraisal

被引:119
作者
Contoli, M. [1 ,2 ]
Bousquet, J. [3 ]
Fabbri, L. M. [4 ]
Magnussen, H. [5 ]
Rabe, K. F. [6 ]
Siafakas, N. M. [7 ]
Hamid, Q. [8 ]
Kraft, M. [9 ]
机构
[1] Univ Ferrara, Res Ctr Asthma, I-44121 Ferrara, Italy
[2] Univ Ferrara, COPD, Dept Clin & Expt Med, I-44121 Ferrara, Italy
[3] Univ Montpellier, Dept Resp Med, F-34059 Montpellier, France
[4] Univ Modena & Reggio Emilia, Dept Resp Med, Modena, Italy
[5] Hosp Grosshansdorf, Ctr Pneumol & Thorac Surg, Grosshansdorf, Germany
[6] Leiden Univ, Med Ctr, Dept Pulmonol, Leiden, Netherlands
[7] Univ Hosp Heraklion, Dept Thorac Med, Iraklion, Greece
[8] McGill Univ, Meakins Christie Labs, Montreal, PQ, Canada
[9] Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA
关键词
airway inflammation; asthma; chronic obstructive pulmonary disease (COPD); small airways; treatment; OBSTRUCTIVE PULMONARY-DISEASE; AIR-FLOW LIMITATION; RESOLUTION COMPUTED-TOMOGRAPHY; HE-3; MAGNETIC-RESONANCE; EXHALED NITRIC-OXIDE; BECLOMETHASONE DIPROPIONATE; INDUCED SPUTUM; PERIPHERAL AIRWAYS; CHLOROFLUOROCARBON BECLOMETHASONE; CLINICAL-APPLICATION;
D O I
10.1111/j.1398-9995.2009.02242.x
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
P>The involvement of small airways in the pathogenesis of asthma and chronic obstructive pulmonary disease (COPD) has been debated for a long time. However, a proper definition of small airway disease is still lacking, and neither a widely accepted biomarker nor a functional parameter to assess small airway abnormalities and to explore the effect of tested compounds on small airways is available. Aiming towards increased knowledge and consensus on this topic, this perspective paper intends to (i) strengthen awareness among the scientific community on the role of small airways in asthma and COPD; (ii) examine the pros and cons of some biological, functional and imaging parameters in the assessment of small airway abnormalities; and (iii) discuss the evidence for distal airway pharmacological targeting in asthma and COPD.
引用
收藏
页码:141 / 151
页数:11
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