Insight and regional brain volumes in schizophrenia

被引：60

作者：

Bassitt, Debora Pastore

Louza Neto, Mario Rodrigues

de Castro, Claudio Campi

Busatto, Geraldo F.

机构：

[1] Univ Sao Paulo, Inst Psychiat, Sch Med, BR-05403010 Sao Paulo, Brazil

[2] Univ Sao Paulo, Magnet Resonance Imaging Sect, Sch Med, BR-05403000 Sao Paulo, Brazil

来源：

EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE | 2007年 / 257卷 / 01期

关键词：

gray matter volume; insight; magnetic resonance; schizophrenia; VOXEL-BASED MORPHOMETRY; ANTERIOR CINGULATE; PREFRONTAL CORTEX; ILLNESS; UNAWARENESS; NEUROCOGNITION; SYMPTOMS; DISORDER;

D O I：

10.1007/s00406-006-0685-z

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We have investigated the relationship between insight impairment and regional brain volumes (gray and white matter) in schizophrenia using voxel-based morphometry (VBM). Fifty patients with schizophrenia were evaluated using the Scale for Unawareness of Mental Disorders. Magnetic resonance images were acquired, segmented and spatially normalized using optimized VBM routines. No significant inverse correlations were detected between insight impairment and gray or white matter volumes in the prefrontal region (where significant findings had been predicted a priori), or in any other brain areas. Our results do not support previous hypotheses suggesting a relationship between frontal lobe atrophy and impaired insight in patients with schizophrenia.

引用

页码：58 / 62

页数：5

共 24 条

[1]

Amador XavierFrancisco., 2004, Insight and Psychosis: Awareness of Illness in Schizophrenia and Related Disorders

[2] Anterior cingulate, gyrus rectus, and orbitofrontal abnormalities in elderly depressed patients: An MRI-based parcellation of the prefrontal cortex [J].