Kidney function and sarcopenia in the United States general population: NHANES III

被引:222
作者
Foley, Robert N.
Wang, Changchun
Ishani, Areef
Collins, Allan J.
Murray, Anne M.
机构
[1] US Renal Data Syst, Coodinating Ctr, Minneapolis, MN 55404 USA
[2] Univ Minnesota, Dept Med, Minneapolis, MN 55455 USA
[3] Hennepin Cty Med Ctr, Dept Med, Minneapolis, MN USA
关键词
chronic kidney disease; glomerular filtration rate; kidney function; muscle mass; NHANES III; sarcopenia;
D O I
10.1159/000101827
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Background/Aims: It is not known whether sarcopenia is associated with levels of kidney function in community-dwelling adults. Methods: Subjects were adult Third National Health and Nutrition Examination Survey participants in whom bioimpedance was performed ( n = 13,770). Class I sarcopenia was defined as a skeletal mass index of 1 - 2 standard deviations below and class II sarcopenia as <2 standard deviations below young adult values. Results: A monotonic association existed between increasing sarcopenia prevalence and declining glomerular filtration rate: >= 90 ml/min/1.73 m(2), 22.8% class I, 3.8% class II sarcopenia; 60-89 ml/min/1.73 m(2), 33.6% class I, 5.3% class II sarcopenia, and <60 ml/min/1.73 m(2), 50.7% class I, 9.4% class II sarcopenia ( p <0.0001). This association dissipated when adjustment was made for older age and more comorbidity. Multivariate associations ( p < 0.05) of sarcopenia and chronic kidney disease included: older age; low income-to-poverty ratio; overweight; lack of exercise; low carbohydrate, fat and protein intake; hypercalcemia; low 25-hydroxy-vitamin D-3; higher diastolic blood pressure, and insulin resistance. Conclusion: Sarcopenia is common in community-dwelling adults with chronic kidney disease. Although causality cannot be assumed, several associations may be susceptible to intervention. Copyright (C) 2007 S. Karger AG, Basel.
引用
收藏
页码:279 / 286
页数:8
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