Gastrointestinal lymphoma: where morphology meets molecular biology

被引：129

作者：

Isaacson, PG

Du, MQ

机构：

[1] UCL, Dept Histopathol, London WC1E 6JJ, England

[2] Univ Cambridge, Dept Pathol, Cambridge CB2 2QQ, England

来源：

JOURNAL OF PATHOLOGY | 2005年 / 205卷 / 02期

关键词：

MALT lymphoma; DLBCL; celiac disease; ETL; BCL10; MALT1;

D O I：

10.1002/path.1703

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Primary gastrointestinal lymphomas are best exemplified by mucosa-associated lymphoid tissue (MALT) lymphoma of the stomach and enteropathy-type T-cell lymphoma (ETL). Both lymphomas were initially recognized on morphological grounds and their identification as distinct clinicopathological entities has subsequently been vindicated following integrated immunophenotypic, molecular, and cellular biological investigations. Delineation of the phenotypic, molecular, and biological properties of these lymphomas at various clinicopathological stages of their development has also provided critical information for the clinical management of patients with these diseases. Here, the histopathology and recent advances in phenotypic and molecular characterization of gastric MALT lymphoma and ETL and their applications in diagnosis and clinical management are reviewed. Copyright (C) 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley Sons, Ltd.

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收藏

页码：255 / 274

页数：20

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