Production of CA125 by human lung cancer cell lines

被引：37

作者：

Homma, S

Satoh, H ^{[1
]}

Kagohashi, K

Fujiwara, M

Kamma, H

Sekizawa, K

机构：

[1] Univ Tsukuba, Inst Clin Med, Div Resp Med, Tsukuba, Ibaraki 3058575, Japan

[2] Kensei Gen Hosp, Dept Pathol, Tsukuba, Ibaraki, Japan

[3] Univ Tsukuba, Inst Basic Med Sci, Tsukuba, Ibaraki 305, Japan

来源：

CLINICAL AND EXPERIMENTAL MEDICINE | 2004年 / 4卷 / 03期

关键词：

CA125; culture; lung cancer; immunostaining;

D O I：

10.1007/s10238-004-0047-y

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

CA125, which until recently was considered an ovary specific tumor marker, is elevated in the serum of patients with many pathological conditions, including lung cancer. In order to investigate the production of CA125 by human lung cancer cell lines, cell culture and immunochemical staining were performed in three cell lines. Our results showed the cell surface expression of CA125 in both adenocarcinoma and large cell carcinoma cell lines and the production of CA125 in culture medium. This is considered as evidence for in vitro production of CA125 by human lung cancer, and suggests that CA125 elevation is not only the result of ovarian cancer but may be due to other pathological conditions, including lung cancer.

引用

页码：139 / 141

页数：3

共 11 条

[1] CA 125 production and release by ovarian cancer cells in vitro [J].