TIMELINE 100 years of Drosophila research and its impact on vertebrate neuroscience: a history lesson for the future

被引:268
作者
Bellen, Hugo J. [1 ,2 ,3 ,4 ]
Tong, Chao [3 ]
Tsuda, Hiroshi [3 ,4 ]
机构
[1] Baylor Coll Med, Program Dev Biol, Houston, TX 77030 USA
[2] Baylor Coll Med, Dept Neurosci, Houston, TX 77030 USA
[3] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA
[4] Baylor Coll Med, Howard Hughes Med Inst, Houston, TX 77030 USA
关键词
CYCLIC-AMP PHOSPHODIESTERASE; CIRCADIAN BEHAVIORAL RHYTHMS; SITE-SPECIFIC RECOMBINATION; FINGER TRANSCRIPTION FACTOR; GROWTH CONE GUIDANCE; ACHAETE-SCUTE SYSTEM; SYNAPTIC-TRANSMISSION; CELL-FATE; NEUROTRANSMITTER RELEASE; GENE-COMPLEX;
D O I
10.1038/nrn2839
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Discoveries in fruit flies have greatly contributed to our understanding of neuroscience. The use of an unparalleled wealth of tools, many of which originated between 1910-1960, has enabled milestone discoveries in nervous system development and function. Such findings have triggered and guided many research efforts in vertebrate neuroscience. After 100 years, fruit flies continue to be the choice model system for many neuroscientists. The combinational use of powerful research tools will ensure that this model organism will continue to lead to key discoveries that will impact vertebrate neuroscience.
引用
收藏
页码:514 / +
页数:10
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