Genetic evaluation of suspected cases of transient HIV-1 infection of infants

被引：53

作者：

Frenkel, LM

Mullins, JI

Learn, GH

Manns-Arcuino, L

Herring, BL

Kalish, ML

Steketee, RW

Thea, DM

Nichols, JE

Liu, SL

Harmache, A

He, X

Muthui, D

Madan, A

Hood, L

Haase, AT

Zupancic, M

Staskus, K

Wolinsky, S

Krogstad, P

Zhao, JQ

Chen, I

Koup, R

Ho, D

Korber, B

Apple, RJ

Coombs, RW

Pahwa, S

Roberts, NJ

机构：

[1] Univ Washington, Dept Pediat, Div Infect Dis, Seattle, WA 98105 USA

[2] Univ Rochester, Dept Pediat, Rochester, NY 14642 USA

[3] Univ Washington, Dept Microbiol, Seattle, WA 98195 USA

[4] Univ Washington, Dept Med, Seattle, WA 98195 USA

[5] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA

[6] Med & Hlth Res Assoc New York City, New York, NY 10013 USA

[7] Univ Rochester, Dept Med, Rochester, NY 14642 USA

[8] Univ Texas, Med Branch, Dept Med & Microbiol & Immunol, Galveston, TX 77555 USA

[9] Univ Washington, Dept Mol Biotechnol, Seattle, WA 98195 USA

[10] Univ Minnesota, Dept Microbiol, Minneapolis, MN 55455 USA

[11] Northwestern Univ, Dept Med, Chicago, IL 60611 USA

[12] Univ Calif Los Angeles, Dept Pediat, Los Angeles, CA 90024 USA

[13] Univ Calif Los Angeles, Dept Med & Microbiol & Immunol, Los Angeles, CA 90024 USA

[14] Aaron Diamond AIDS Res Ctr, New York, NY 10016 USA

[15] Santa Fe Inst, Los Alamos, NM 87545 USA

[16] Roche Mol Diagnost, Alameda, CA 94501 USA

[17] NYU, N Shore Hosp, Dept Pediat, Manhasset, NY 11030 USA

来源：

SCIENCE | 1998年 / 280卷 / 5366期

关键词：

D O I：

10.1126/science.280.5366.1073

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Detection of human immunodeficiency virus-type 1 (HIV-1) on only one or a few occasions in infants born to infected mothers has been interpreted to indicate that infection may be transient rather than persistent. Forty-two cases of suspected transient HIV-1 viremia among 1562 perinatally exposed seroreverting infants and one mother were reanalyzed. HIV-1 env sequences were not found in specimens from 20; in specimens from 6, somatic genetic analysis revealed that specimens were mistakenly attributed to an infant; and in specimens from 17, phylogenetic analysis failed to demonstrate the expected linkage between the infant's and the mother's virus. These findings argue that transient HIV-1 infection, if it exists, will only rarely be satisfactorily documented.

引用

页码：1073 / 1077

页数：5

共 22 条

[1] LYMPHOCYTE PROLIFERATIVE RESPONSES TO HIV-1 ENVELOPE AND CORE ANTIGENS BY INFECTED AND UNINFECTED ADULTS AND CHILDREN
BORKOWSKY, W
KRASINSKI, K
MOORE, T
PAPAEVANGELOU, V
[J]. AIDS RESEARCH AND HUMAN RETROVIRUSES, 1990, 6 (05) : 673 - 678
[2] CLEARANCE OF HIV-INFECTION IN A PERINATALLY INFECTED INFANT
BRYSON, YJ
PANG, S
WEI, LS
DICKOVER, R
DIAGNE, A
CHEN, ISY
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1995, 332 (13) : 833 - 838
[3] Maternal HIV-1 viral load and vertical transmission of infection: The Ariel Project for the Prevention of HIV Transmission from Mother to Infant
Cao, YZ
Krogstad, P
Korber, BT
Koup, RA
Muldoon, M
Macken, C
Song, JL
Jin, ZQ
Zhao, JQ
Clapp, S
Chen, ISY
Ho, DD
Ammann, AJ
Mullins, J
Walker, B
Wolinsky, S
Bardeguez, A
Crane, M
Hanson, C
Hamill, H
Luzuriaga, K
Palumbo, P
VanDyke, R
Widmayer, S
Wiznia, A
[J]. NATURE MEDICINE, 1997, 3 (05) : 549 - 552
[4] CONNOR EM, 1995, PEDIATR INFECT DIS J, V14, P536, DOI 10.1097/00006454-199506000-00012
[5] Mother-to-infant transmission of human immunodeficiency virus type 1 involving five envelope sequence subtypes
Contag, CH
Ehrnst, A
Duda, J
Bohlin, AB
Lindgren, S
Learn, GH
Mullins, JI
[J]. JOURNAL OF VIROLOGY, 1997, 71 (02) : 1292 - 1300
[6] GENETIC-RELATIONSHIPS DETERMINED BY A DNA HETERODUPLEX MOBILITY ASSAY - ANALYSIS OF HIV-1 ENV GENES
DELWART, EL
SHPAER, EG
LOUWAGIE, J
MCCUTCHAN, FE
GREZ, M
RUBSAMENWAIGMANN, H
MULLINS, JI
[J]. SCIENCE, 1993, 262 (5137) : 1257 - 1261
[7] DELWART EL, 1995, AIDS RES HUM RETROV, V11, P1181
[8] EFFECTS OF ZIDOVUDINE USE DURING PREGNANCY ON RESISTANCE AND VERTICAL TRANSMISSION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1
FRENKEL, LM
WAGNER, LE
DEMETER, LM
DEWHURST, S
COOMBS, RW
MURANTE, BL
REICHMAN, RC
[J]. CLINICAL INFECTIOUS DISEASES, 1995, 20 (05) : 1321 - 1326
[9] FRENKEL LM, UNPUB
[10] HOFFENBACH A, 1989, J IMMUNOL, V142, P452

← 1 2 3 →