Theory and statistics of detecting synergism between two active drugs: cocaine and buprenorphine

被引:31
作者
Tallarida, RJ [1 ]
Kimmel, HL [1 ]
Holtzman, SG [1 ]
机构
[1] EMORY UNIV, SCH MED, DEPT PHARMACOL, ATLANTA, GA 30322 USA
关键词
buprenorphine; cocaine; drug interactions; isobologram; statistics; synergism;
D O I
10.1007/s002130050417
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
This article discusses the theory and statistical aspects in the design and analysis of experiments to detect synergism between two drugs that produce overtly similar effects. The current analysis extends and simplifies previously published work in this area. Application is made to a study by Kimmel et al. in this issue that examined the combined action of buprenorphine and cocaine in producing turning in rats having unilateral nigrostriatal lesions produced by 6-hydroxydopamine. The use of turning as an endpoint is unusual in quantitative studies of synergism in that no clear maximum effect (turning), could be elicited. Data from the turning study are analyzed statistically and reveal that the combination of buprenorphine and cocaine in each of two fixed ratio mixtures tested is synergistic for this effect.
引用
收藏
页码:378 / 382
页数:5
相关论文
共 12 条
[1]  
Fieller E. C., 1944, QUART J PHARM PHARMA, V17, P117
[2]  
Finney D.J., 1977, PROBIT ANAL, VIII
[3]   Synergism between buprenorphine and cocaine on the rotational behavior of the nigrally-lesioned rat [J].
Kimmel, HL ;
Tallarida, RJ ;
Holtzman, SG .
PSYCHOPHARMACOLOGY, 1997, 133 (04) :372-377
[4]   SPINAL ANTINOCICEPTIVE SYNERGY BETWEEN CLONIDINE AND MORPHINE, U69593, AND DPDPE - ISOBOLOGRAPHIC ANALYSIS [J].
OSSIPOV, MH ;
LOZITO, R ;
MESSINEO, E ;
GREEN, J ;
HARRIS, S ;
LLOYD, P .
LIFE SCIENCES, 1990, 47 (16) :PL71-PL76
[5]   SITES OF CLONIDINE ACTION TO INHIBIT GUT PROPULSION IN MICE - DEMONSTRATION OF A CENTRAL COMPONENT [J].
QI, J ;
SHELDON, RJ ;
PORRECA, F .
GASTROENTEROLOGY, 1988, 95 (05) :1265-1271
[6]  
ROERIG SC, 1988, J PHARMACOL EXP THER, V247, P603
[7]  
Tallarida R., 1987, MANUAL PHARM CALCULA
[8]   STATISTICAL-ANALYSIS OF DRUG-DRUG AND SITE-SITE INTERACTIONS WITH ISOBOLOGRAMS [J].
TALLARIDA, RJ ;
PORRECA, F ;
COWAN, A .
LIFE SCIENCES, 1989, 45 (11) :947-961
[9]   STATISTICAL-ANALYSIS OF DRUG-COMBINATIONS FOR SYNERGISM [J].
TALLARIDA, RJ .
PAIN, 1992, 49 (01) :93-97
[10]   APPROACHES TO THE STUDY OF DRUG-INTERACTIONS IN BEHAVIORAL PHARMACOLOGY [J].
WESSINGER, WD .
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 1986, 10 (02) :103-113