Polyamines and neoplastic growth

被引：51

作者：

Pegg, A. E. ^{[1
]}

Feith, D. J. ^{[1
]}

机构：

[1] Penn State Univ, Coll Med, Dept Cellular & Mol Physiol, Hershey, PA 17033 USA

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2007年 / 35卷

关键词：

antizyme; anlizyme inhibitor; ornithine decarboxylase (ODC); putrescine; spermidine; spermidine/spermine-N-1-acetyltransferase (SSAT);

D O I：

10.1042/BST0350295

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Studies over many years have suggested that increased polyamine synthesis may be necessary for neoplastic growth. This review summarizes recent work on the regulation of putrescine production both de novo and via the degradation of higher polyamines and provides a summary of studies using transgenic mice in which the levels of proteins that regulate these processes (L-ornithine decarboxylase, antizyme and spermidine/spermine-N-1-acetyltransferase) are altered.

引用

页码：295 / 299

页数：5

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