Tissue-Engineered Tracheal Transplantation

被引：73

作者：

Baiguera, Silvia ^{[1
]}

Birchall, Martin A. ^{[2
]}

Macchiarini, Paolo ^{[1
]}

机构：

[1] Univ Florence, BIOAIR Lab Biomol & Bioengn Airways, I-50134 Florence, Italy

[2] Royal Natl Throat Nose & Ear Hosp, UCL Ear Inst, London WC1X 8DA, England

来源：

TRANSPLANTATION | 2010年 / 89卷 / 05期

关键词：

Allogeneic human trachea; Acellular matrix; Autologous human cells; Recellularization; Clinical transplantation; RESPIRATORY EPITHELIAL-CELLS; MESENCHYMAL STEM-CELLS; IN-VITRO; BIODEGRADABLE MATERIALS; ACELLULAR MATRIX; CARTILAGE; CHONDROCYTES; RECONSTRUCTION; REGENERATION; REPLACEMENT;

D O I：

10.1097/TP.0b013e3181cd4ad3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Regenerative medicine offers new tools with which to tackle disorders for which there is currently no good therapeutic option. The trachea is an ideal organ in which to explore the clinical potential of tissue engineering because severe large airway disease is poorly managed by conventional treatments, and the success of a graft is determined only by its ability to conduct air lifelong: that is, whether it can become a sustainable biological conduit. We define the component parts of tissue engineering and review the experimental methods used to produce airway implants to date, including a recent successful, first-in-man experience.

引用

页码：485 / 491

页数：7

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