Effect of low-power pulsed laser on peripheral nerve regeneration in rats

被引：45

作者：

Chen, YS ^{[1
]}

Hsu, SF

Chiu, CW

Lin, JG

Chen, CT

Yao, CH

机构：

[1] China Med Univ, Inst Chinese Med Sci, Taichung 404, Taiwan

[2] China Med Univ, Acupuncture Res Ctr, Taichung, Taiwan

[3] Changhua Christian Hosp, Div Emergency Med, Changhua, Taiwan

[4] Taipei Municipal Hosp Tradit Chinese Med, Taipei, Taiwan

[5] Chung Tai Inst Hlth Sci & Technol, Dept Radiol Technol, Taichung, Taiwan

来源：

MICROSURGERY | 2005年 / 25卷 / 01期

关键词：

D O I：

10.1002/micr.20079

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

The purpose of this study was to determine whether low-power pulsed laser irradiation could affect the regeneration of a 10-mm gap of rat sciatic nerve created between the proximal and distal nerve stumps, which were sutured into silicone rubber tubes. After 8 weeks of recovery, pulsed laser-irradiated groups at frequencies of 5 kHz and 20 kHz both had significantly lower success percentages of regeneration (50% and 44%, respectively) compared to sham-irradiated controls (100%). In addition, qualitative and quantitative histology of the regenerated nerves revealed a less mature ultrastructural organization with a smaller cross-sectional area and a lower number of myelinated axons in both pulsed laser-irradiated groups than in controls. These results suggest that pulsed laser irradiation could elicit suppressing effects on regenerating nerves. (C) 2004 Wiley-Liss, Inc.

引用

页码：83 / 89

页数：7

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