Drug dependence, a chronic medical illness - Implications for treatment, insurance, and outcomes evaluation

被引:1715
作者
McLellan, AT
Lewis, DC
O'Brien, CP
Kleber, HD
机构
[1] Treatment Res Inst, Philadelphia, PA 19106 USA
[2] Vet Affairs Med Ctr, Penn VA Ctr Studies Addict, Philadelphia, PA USA
[3] Univ Penn, Philadelphia, PA 19104 USA
[4] Brown Univ, Ctr Alcohol & Addict Studies, Providence, RI 02912 USA
[5] Columbia Univ, Natl Ctr Addict & Subst Abuse, New York, NY USA
来源
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION | 2000年 / 284卷 / 13期
关键词
D O I
10.1001/jama.284.13.1689
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The effects of drug dependence on social systems has helped shape the generally held view that drug dependence is primarily a social problem, not a health problem. In turn, medical approaches to prevention and treatment are lacking, We examined evidence that drug (including alcohol) dependence is a chronic medical illness. A literature review compared the diagnoses, heritability, etiology (genetic and environmental factors), pathophysiology, and response to treatments (adherence and relapse) of drug dependence vs type 2 diabetes mellitus, hypertension, and asthma, Genetic heritability, personal choice, and environmental factors are comparably involved in the etiology and course of all of these disorders. Drug dependence produces significant and lasting changes in brain chemistry and function. Effective medications are available for treating nicotine, alcohol, and opiate dependence but not stimulant or marijuana dependence, Medication adherence and relapse rates are similar across these illnesses. Drug dependence generally has been treated as if it were an acute illness, Review results suggest that long-term care strategies of medication management and continued monitoring produce lasting benefits. Drug dependence should be insured, treated, and evaluated like other chronic illnesses.
引用
收藏
页码:1689 / 1695
页数:7
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