Probing degeneracy in T-cell recognition using peptide combinatorial libraries

被引：112

作者：

Hemmer, B ^{[1
]}

Vergelli, M

Pinilla, C

Houghten, R

Martin, R

机构：

[1] NINDS, Cellular Immunol Sect, Neuroimmunol Branch, NIH, Bethesda, MD 20892 USA

[2] Univ Maryland, Dept Neurol, Baltimore, MD 21201 USA

[3] Torrey Pines Inst Mol Studies, San Diego, CA 92121 USA

[4] Multiple Peptide Syst, San Diego, CA 92121 USA

来源：

IMMUNOLOGY TODAY | 1998年 / 19卷 / 04期

关键词：

D O I：

10.1016/S0167-5699(97)01217-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent studies have demonstrated flexibility of the T-cell receptor (TCX) with respect to recognition of peptide bound to self major histocompatibility complex (MHC). With the introduction of peptide combinatorial libraries, it has become possible to dissect the extent of degeneracy in T-cell recognition. On the basis of these novel findings, Bernhard Hemmer and colleagues propose a conceptual framework for lymphocyte selection and survival and the occurrence of autoimmunity.

引用

页码：163 / 168

页数：6

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