Glycogen synthase kinase-3β -: Actively inhibiting hypertrophy

被引：42

作者：

Kerkela, Risto ^{[1
]}

Woulfe, Kathleen ^{[1
]}

Force, Thomas ^{[1
]}

机构：

[1] Jefferson Med Coll, Ctr Translat Med, Philadelphia, PA 19107 USA

来源：

TRENDS IN CARDIOVASCULAR MEDICINE | 2007年 / 17卷 / 03期

关键词：

CARDIAC MYOCYTE HYPERTROPHY; PROTEIN-KINASE; IN-VIVO; CELL-GROWTH; CARDIOMYOCYTE HYPERTROPHY; DEPENDENT TRANSCRIPTION; SIGNALING PATHWAYS; BETA-CATENIN; COLON-CANCER; C-MYC;

D O I：

10.1016/j.tcm.2007.01.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A number of signaling pathways are involved in the regulation of cardiac hypertrophy and remodeling. One that serves as an integrator of upstream inputs, and as a transducer to downstream effectors, is the protein kinase, glycogen synthase kinase-3 beta. In this work we review the role of this putative "nodal point" in the response of the heart to growth stimuli, both physiologic and pathologic.

引用

页码：91 / 96

页数：6

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