The corridor task:: Striatal lesion effects and graft-mediated recovery in a model of Huntington's disease

被引：13

作者：

Dobrossy, Mate D. ^{[1
]}

Dunnett, Stephen B. ^{[1
]}

机构：

[1] Univ Cardiff Wales, Brain Repair Grp, Sch Biosci, Cardiff CF10 3US, Wales

来源：

BEHAVIOURAL BRAIN RESEARCH | 2007年 / 179卷 / 02期

基金：

英国医学研究理事会;

关键词：

corridor task; striatal lesions; embryonic grafts; Huntington's disease; neurotransplantation;

D O I：

10.1016/j.bbr.2007.02.030

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Experimental validation of cell replacement therapy as a treatment of neurodegenerative diseases requires the demonstration of graft-mediated behavioural recovery. The Corridor task proved to be simple and efficient to conduct with a robust ipsilateral retrieval bias in our rodent Huntington's disease model. The Corridor task is a viable behavioural option, particularly to non-specialised laboratories, for the evaluation of lateralised striatal damage and the probing of alternative therapeutic strategies, including transplantation. (c) 2007 Elsevier B.V. All rights reserved.

引用

页码：326 / 330

页数：5

共 20 条

[1] Effect of fetal neural transplants inpatients with Huntington's disease 6 years after surgery:: a long-term follow-up study [J].

Bachoud-Lévi, AC ;

Gaura, V ;

Brugières, P ;

Lefaucheur, JP ;

Boissé, MF ;

Maison, P ;

Baudic, S ;

Ribeiro, MJ ;

Bourdet, C ;

Remy, P ;

Cesaro, P ;

Hantraye, P ;

Peschanski, M .

LANCET NEUROLOGY, 2006, 5 (04) :303-309

[2] Cell replacement therapies for central nervous system disorders [J].

Björklund, A ;

Lindvall, O .

NATURE NEUROSCIENCE, 2000, 3 (06) :537-544

[3] Behavioral recovery after transplantation into a rat model of Huntington's disease: Dependence on anatomical connectivity and extensive postoperative training [J].

Brasted, PJ ;

Watts, C ;

Torres, EM ;

Robbins, TW ;

Dunnett, SB .

BEHAVIORAL NEUROSCIENCE, 2000, 114 (02) :431-436

[4] Striatal lesions produce distinctive impairments in reaction time performance in two different operant chambers [J].

Brasted, PJ ;

Döbrössy, MD ;

Robbins, TW ;

Dunnett, SB .

BRAIN RESEARCH BULLETIN, 1998, 46 (06) :487-493

[5] The effects of lateralized training on spontaneous forelimb preference, lesion deficits, and graft-mediated functional recovery after unilateral striatal lesions in rats [J].

Dobrossy, Mate D. ;

Dunnett, Stephen B. .

EXPERIMENTAL NEUROLOGY, 2006, 199 (02) :373-383

[6] Training specificity, graft development and graft-mediated functional recovery in a rodent model of Huntington's disease [J].

Döbrössy, MD ;

Dunnett, SB .

NEUROSCIENCE, 2005, 132 (03) :543-552

[7] The Corridor Task: A simple test of lateralised response selection sensitive to unilateral dopamine deafferentation and graft-derived dopamine replacement in the striatum [J].

Dowd, E ;

Monville, C ;

Torres, EM ;

Dunnett, SB .

BRAIN RESEARCH BULLETIN, 2005, 68 (1-2) :24-30

[8]

Dunnett Stephen B, 2004, NeuroRx, V1, P394, DOI 10.1007/BF03206626

[9] Further validation of the corridor task for assessing deficit and recovery in the hemi-Parkinsonian rat: Restoration of bilateral food retrieval by dopamine receptor agonism [J].

Fitzsimmons, DF ;

Moloney, TC ;

Dowd, E .

BEHAVIOURAL BRAIN RESEARCH, 2006, 169 (02) :352-355

[10] The effects of donor stage on the survival and function of embryonic striatal grafts in the adult rat brain .2. Correlation between positron emission tomography and reaching behaviour [J].

Fricker, RA ;

Torres, EM ;

Hume, SP ;

Myers, R ;

OpackaJuffrey, J ;

Ashworth, S ;

Brooks, DJ ;

Dunnett, SB .

NEUROSCIENCE, 1997, 79 (03) :711-721

← 1 2 →