Aromatic L-amino acid decarboxylase is present in serotonergic fibers of the striatum of the rat. A double-labeling immunofluorescence study

被引：68

作者：

Arai, R

Karasawa, N

Nagatsu, I

机构：

[1] Department of Anatomy, Fujita Hlth. Univ. Sch. of Medicine, Toyoake

来源：

BRAIN RESEARCH | 1996年 / 706卷 / 01期

关键词：

aromatic L-amino acid decarboxylase; serotonergic neuron; L-Dopa; dopamine; raphe nucleus; striatum; cerebral cortex; Parkinson's disease;

D O I：

10.1016/0006-8993(95)01281-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The aim of the present study is to examine whether serotonergic fibers of the striatum of the rat contain aromatic L-amino acid decarboxylase (AADC). By use of a double-labeling immunofluorescence method, we showed that AADC was localized in serotonergic fibers of the striatum and cerebral cortex as well as in serotonergic cell bodies of the midbrain raphe nuclei. We previously demonstrated that serotonergic fibers of the rat striatum contained dopamine after intraperitoneal injection of L-dopa. These findings suggest that dopamine is produced from the injected L-dopa in serotonergic fibers of the rat striatum.

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页码：177 / 179

页数：3

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