GSTT1 and GSTM1 null genotypes may facilitate hepatitis C virus infection becoming chronic

被引：16

作者：

Martinez, Carmen

Garcia-Martin, Elena

Ladero, Jose M.

Herraez, Oscar

Ortega, Luis

Taxonera, Carlos

Suarez, Avelina

Diaz-Rubio, Manuel

Agundez, Jose A. G.

机构：

[1] Univ Complutense Madrid, Liver Unit, Gastroenterol Serv, Hosp Clin San Carlos, Madrid 28040, Spain

[2] Univ Complutense Madrid, Serv Pathol, Hosp Clin San Carlos, Madrid 28040, Spain

[3] Univ Complutense Madrid, Microbiol Serv, Hosp Clin San Carlos, Madrid 28040, Spain

[4] Univ Extremadura, Dept Pharmacol & Psychiat, Badajoz, Spain

[5] Univ Extremadura, Dept Biochem, Badajoz, Spain

[6] Univ Extremadura, Dept Mol Biol, Badajoz, Spain

[7] Univ Extremadura, Dept Genet, Badajoz, Spain

来源：

JOURNAL OF INFECTIOUS DISEASES | 2007年 / 195卷 / 09期

关键词：

D O I：

10.1086/513569

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Oxidative stress contributes to hepatitis C virus (HCV)-induced liver damage. The activity of antioxidant glutathione S-transferases (GSTs) T1 and M1 is polymorphic. The GSTT1 and GSTM1 genotypes were identified in 139 HCV-infected patients and in 329 healthy individuals. Among patients, there was an excess of GSTT1 (odds ratio [OR], 2.76 [95%confidence interval {CI}, 1.77 - 4.30]; P < .001) and GSTM1 (OR, 1.54 [95% CI, 1.02 - 2.35];) null genotypes and of double-null haplotypes (OR, 3.65 [95% CI, 1.98 - 6.75];). The GSTT1 null genotype, particularly if associated P < .001 with the GSTM1 null genotype, may facilitate HCV infection becoming chronic.

引用

收藏

页码：1320 / 1323

页数：4

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