Adherence to a Mediterranean diet and risk of gastric adenocarcinoma within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort study

被引：172

作者：

Buckland, Genevieve ^{[1
]}

Agudo, Antonio ^{[1
]}

Lujan, Leila ^{[1
]}

Jakszyn, Paula ^{[1
]}

Bueno-de-Mesquita, H. Bas ^{[2
]}

Palli, Domenico ^{[3
]}

Boeing, Heiner ^{[4
]}

Carneiro, Fatima ^{[5
,6
]}

Krogh, Vittorio ^{[7
]}

Sacerdote, Carlotta ^{[8
]}

Tumino, Rosario ^{[9
]}

Panico, Salvatore ^{[10
]}

Nesi, Gabriella ^{[11
]}

Manjer, Jonas ^{[12
]}

Regner, Sara ^{[12
]}

Johansson, Ingegerd ^{[13
]}

Stenling, Roger ^{[14
]}

Sanchez, Maria-Jose ^{[15
,16
]}

Dorronsoro, Miren ^{[17
]}

Barricarte, Aurelio ^{[18
]}

Navarro, Carmen ^{[16
,19
]}

Ramon Quiros, J. ^{[20
]}

Allen, Naomi E. ^{[21
]}

Key, Timothy J. ^{[21
]}

Bingham, Sheila ^{[22
,23
,24
]}

Kaaks, Rudolf ^{[25
]}

Overvad, Kim ^{[26
]}

Jensen, Majken ^{[26
]}

Olsen, Anja ^{[27
]}

Tjonneland, Anne ^{[27
]}

Peeters, Petra H. M. ^{[28
]}

Numans, Mattijs E. ^{[28
]}

Ocke, Marga C. ^{[29
]}

Clavel-Chapelon, Francoise ^{[30
]}

Morois, Sophie ^{[30
]}

Boutron-Ruault, Marie-Christine ^{[30
]}

Trichopoulou, Antonia ^{[31
]}

Lagiou, Pagona ^{[31
]}

Trichopoulos, Dimitrios ^{[32
]}

Lund, Eiliv ^{[33
]}

Couto, Elisabeth ^{[34
]}

Boffeta, Paolo ^{[34
]}

Jenab, Mazda ^{[34
]}

Riboli, Elio ^{[35
]}

Romaguera, Dora ^{[35
]}

Mouw, Traci ^{[35
]}

Gonzalez, Carlos A. ^{[1
]}

机构：

[1] Catalan Inst Oncol, Canc Epidemiol Res Programme, Unit Nutr Environm & Canc, Barcelona, Spain

[2] Natl Inst Publ Hlth & Environm, NL-3720 BA Bilthoven, Netherlands

[3] Sci Inst Tuscany, CSPO, Mol & Nutr Epidemiol Unit, Florence, Italy

[4] German Inst Human Nutr, Potsdam, Germany

[5] Univ Porto, Inst Mol Pathol & Immunol, P-4100 Oporto, Portugal

[6] HS Joao, Fac Med, Oporto, Portugal

[7] Natl Inst Tumori, Nutr Epidemiol Unit, Dept Prevent & Predict Med, Milan, Italy

[8] Univ Turin, Turin, Italy

[9] Azienda Osped Civile MP Arezzo, Canc Registry, Ragusa, Italy

[10] Univ Naples Federico II, Dept Clin & Expt Med, Naples, Italy

[11] Univ Florence, Dept Human Pathol & Oncol, Florence, Italy

[12] Malmo Univ Hosp, Dept Surg, Malmo, Sweden

[13] Umea Univ, Dept Nutr Res, Umea, Sweden

[14] Umea Univ, Dept Med Biosci, Umea, Sweden

[15] Andalusian Sch Publ Hlth, Granada, Spain

[16] CIBER Epidemiol & Salud Publ, Murcia, Spain

[17] Dept Publ Hlth Guipuzkoa, San Sebastian, Spain

[18] Publ Hlth Inst Navarra, Pamplona, Spain

[19] Hlth Council Murcia, Dept Epidemiol, Murcia, Spain

[20] Publ Hlth & Hlth Planning Directorate, Asturias, Spain

[21] Univ Oxford, Canc Epidemiol Unit, Oxford, England

[22] Univ Cambridge, MRC Dunn Human Nutr Unit, Cambridge, England

[23] Univ Cambridge, MRC Ctr Nutr Epidemiol Canc Prevent & Survival, Cambridge, England

[24] Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England

[25] Deutsch Krebsforschungszentrum, Div Clin Epidemiol, D-6900 Heidelberg, Germany

[26] Aarhus Univ Hosp, Dept Clin Epidemiol, Aalborg, Denmark

[27] Danish Canc Soc, Inst Canc Epidemiol, Copenhagen, Denmark

[28] Univ Med Ctr, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[29] Natl Inst Publ Hlth & Environm, NL-3720 BA Bilthoven, Netherlands

[30] Inst Gustave Roussy, INSERM, F-94805 Villejuif, France

[31] Univ Athens, Sch Med, Greece & Hellen Hlth Fdn, Dept Hyg & Epidemiol, GR-11527 Athens, Greece

[32] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[33] Univ Tromso, Inst Community Med, Tromso, Norway

[34] Int Agcy Res Canc, F-69372 Lyon, France

[35] Univ London Imperial Coll Sci Technol & Med, Div Epidemiol Publ Hlth & Primary Care, Fac Med, London, England

来源：

AMERICAN JOURNAL OF CLINICAL NUTRITION | 2010年 / 91卷 / 02期

关键词：

BREAST-CANCER; LIFE-STYLE; PATTERN; MORTALITY; SURVIVAL; QUALITY; HEALTH; WOMEN; CONSUMPTION; POPULATION;

D O I：

10.3945/ajcn.2009.28209

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Background: The Mediterranean dietary pattern is believed to protect against cancer, although evidence from cohort studies that have examined particular cancer sites is limited. Objective: We aimed to explore the association between adherence to a relative Mediterranean diet (rMED) and incident gastric adenocarcinoma (GC) within the European Prospective Investigation into Cancer and Nutrition study. Design: The study included 485,044 subjects (144,577 men) aged 35-70 y from 10 European countries. At recruitment, dietary and lifestyle information was collected. An 18-unit rMED score, incorporating 9 key components of the Mediterranean diet, was used to estimate rMED adherence. The association between rMED and GC with respect to anatomic location (cardia and noncardia) and histologic types (diffuse and intestinal) was investigated. A calibration study in a subsample was used to control for dietary measurement error. Results: After a mean follow-up of 8.9 y, 449 validated incident GC cases were identified and used in the analysis. After stratification by center and age and adjustment for recognized cancer risk factors, high compared with low rMED adherence was associated with a significant reduction in GC risk (hazard ratio: 0.67; 95% CI: 0.47, 0.94). A 1-unit increase in the rMED score was associated with a decreased risk of GC of 5% (95% CI: 0.91, 0.99). There was no evidence of heterogeneity between different anatomic locations or histologic types. The calibrated results showed similar trends (overall hazard ratio for GC: 0.93; 95% CI: 0.89, 0.99). Conclusion: Greater adherence to an rMED is associated with a significant reduction in the risk of incident GC. Am J Clin Nutr 2010:91:381-90.

引用

页码：381 / 390

页数：10

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