Selective inhibition of the chymotrypsin-like activity of the 20S proteasome by 5-methoxy-1-indanone dipeptide benzamides

被引：35

作者：

Lum, RT ^{[1
]}

Nelson, MG ^{[1
]}

Joly, A ^{[1
]}

Horsma, AG ^{[1
]}

Lee, G ^{[1
]}

Meyer, SM ^{[1
]}

Wick, MM ^{[1
]}

Schow, SR ^{[1
]}

机构：

[1] CV Therapeut Inc, Palo Alto, CA 94304 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 03期

关键词：

D O I：

10.1016/S0960-894X(98)00015-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Potent inhibitors of the 20S proteasome that contain a novel indanone head group coupled to di and tripeptides are described. These compounds are the first proteasome inhibitors have demonstrated high selectivity for the chymotrypsin-like activity of the 20S proteasome. (C) 1998 Elsevier Science Ltd. All rights reserved.

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收藏

页码：209 / 214

页数：6

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