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The suppressor of cytokine signalling-1 (SOCS-1) gene is overexpressed in Philadelphia chromosome negative chronic myeloproliferative disorders

被引：8
作者：
Bock, Oliver
Hussein, Kais
Brakensiek, Kai
Buhr, Thomas
Schlue, Jerome
Wiese, Birgitt
Kreipe, Hans
机构：
[1] Hannover Med Sch, Inst Pathol, D-30625 Hannover, Germany
[2] Hannover Med Sch, Inst Biometr, D-30625 Hannover, Germany
来源：
LEUKEMIA RESEARCH | 2007年 / 31卷 / 06期
关键词：
chronic mveloproliferative disorders; SOCS-1; JAK2; bone marrow cells; real-time RT-PCR;
D O I：
10.1016/j.leukres.2006.08.022
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The suppressor of cytokine signalling-1 (SOCS-1) is a negative regulator of signal transduction mediated by cytoplasmic tyrosine kinases such as the Janus kinases (JAKs). We investigated SOCS-I expression in bone marrow cells from Philadelphia chromosome negative chronic myeloproliferative disorders (Ph- CMPD) and normal haematopoiesis (n = 121), and additionally in peripheral blood samples (n = 18). Except for chronic idiopathic myelofibrosis harbouring wild-type JAK2, other Ph- CMPD expressed significantly higher SOCS-1 levels of up to 14-fold compared to the control group (p < 0.001) independent of the JAK2 status. The mononuclear cell fraction but not granulocytes in patients with Polycythaemia vera also significantly overexpressed SOCS-1. We conclude that up-regulation of the SOCS-1 gene might reflect a compensatory feedback mechanism with different emphasis among Ph- CMPD subtypes independent of an underlying JAK2 (V617F) mutation. (c) 2006 Elsevier Ltd. All rights reserved.
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收藏
页码：799 / 803
页数：5
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