Identity of the putative δ1-opioid receptor as a δ-κ heteromer in the mouse spinal cord

被引：44

作者：

Portoghese, PS ^{[1
]}

Lunzer, MA ^{[1
]}

机构：

[1] Univ Minnesota, Coll Pharm, Dept Med Chem, Minneapolis, MN 55455 USA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2003年 / 467卷 / 1-3期

关键词：

delta(1)-opioid receptor; delta-kappa heteromer; norbinaltorphimine;

D O I：

10.1016/S0014-2999(03)01599-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In view of the co-localization of spinal delta- and kappa-opioid receptors, we have investigated the interaction of selective opioid receptor agonists and antagonists in the spinal cord of mice in order to determine if these receptors are organized as heteromers. The finding that norbinaltorphimine (kappa) antagonized [D-Pen(2,5)]enkephalin (delta(1)), but not deltorphin II (delta(2)), strongly suggests that the putative delta(1)-subtype is a delta-kappa heteromer. Studies with selective opioid receptor (ant)agonists support this conclusion. (C) 2003 Elsevier Science B.V. All rights reserved.

引用

页码：233 / 234

页数：2

共 8 条

[1] G-protein-coupled receptor heterodimerization modulates receptor function [J].

Jordan, BA ;

Devi, LA .

NATURE, 1999, 399 (6737) :697-700

[2]

MATTIA A, 1991, J PHARMACOL EXP THER, V258, P583

[3] KAPPA-OPIOID AND DELTA-OPIOID AGONISTS SYNERGIZE TO PRODUCE POTENT ANALGESIA [J].

MIASKOWSKI, C ;

TAIWO, YO ;

LEVINE, JD .

BRAIN RESEARCH, 1990, 509 (01) :165-168

[4]

Poonyachoti S, 2001, J PHARMACOL EXP THER, V297, P69

[5]

SOFUOGLU M, 1991, J PHARMACOL EXP THER, V257, P676

[6]

TULUNAY FC, 1974, J PHARMACOL EXP THER, V190, P395

[7] Mechanisms of opioid-induced pain and antinociceptive tolerance: descending facilitation and spinal dynorphin [J].

Vanderah, TW ;

Ossipov, MH ;

Lai, J ;

Malan, TP ;

Porreca, F .

PAIN, 2001, 92 (1-2) :5-9

[8] Coexistence of kappa- and delta-opioid receptors in rat spinal cord axons [J].

Wessendorf, MW ;

Dooyema, J .

NEUROSCIENCE LETTERS, 2001, 298 (03) :151-154

← 1 →