Chronic lung inflammation in aging mice

被引：36

作者：

Aoshiba, Kazutetsu ^{[1
]}

Nagai, Atsushi ^{[1
]}

机构：

[1] Tokyo Womens Med Univ, Dept Med 1, Shinjuku Ku, Tokyo 1628666, Japan

来源：

FEBS LETTERS | 2007年 / 581卷 / 18期

关键词：

aging; inflammation; lung; lymphocytes; macrophages; cytokine;

D O I：

10.1016/j.febslet.2007.06.075

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To determine whether aging is associated with a pro-inflammatory shift in the lung, inflammation and inflammation-related gene expression in the lungs of 12-week-old and 24month-old Balb/c mice were studied. cDNA microarray and quantitative reverse transcription-polymerase chain reaction analyses showed that eight inflammation-related genes, including CD20, Burkitt lymphoma receptor 1, CXCR-3, provirus integration site for Moloney murine leukemia virus-2, CD72, IL-8RB, C-Fgr, and CD8 beta, were upregulated in the aged mice. Immunohistochemistry showed that the lungs of the aged mice contained increased numbers of CD4 cells, CD8 cells, B cells and macrophages. These results suggest that a pro-inflammatory shift occurs in the lungs of mice with aging. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：3512 / 3516

页数：5

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