Improved iterative olefination approach to oligosaccharide mimics:: stereoselective synthesis of β-(1→6)-D-galactopentaose methylene isostere

被引：17

作者：

Dondoni, A ^{[1
]}

Mizuno, M ^{[1
]}

Marra, A ^{[1
]}

机构：

[1] Univ Ferrara, Dipartmento Chim, Chim Organ Lab, I-44100 Ferrara, Italy

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 34期

关键词：

glycomimetics; glycosidase inhibitors; oligosaccharide isosteres; Wittig reaction;

D O I：

10.1016/S0040-4039(00)01112-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The title C-pentagalactoside featuring beta-(1-->6) ethylene bridges between the D-galactopyranose units has been prepared through four consecutive cycles comprising the Wittig reaction of a formyl C-galactoside building block with sugar phosphorane substrate followed by the introduction of a methylphosphonium group at the nonreducing end; the target product was obtained by hydrogenolysis of the tetraene pentasaccharide. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：6657 / 6660

页数：4

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